Quantifying the effects of quadrupolar sinks via 15N relaxation dynamics in metronidazoles hyperpolarized via SABRE-SHEATH

Birchall, Jonathan R., Mohammad S. H. Kabir, Oleg G. Salnikov, Nikita V. Chukanov, Alexandra Svyatova, Kirill V. Kovtunov, Igor V. Koptyug, et al. “Quantifying the Effects of Quadrupolar Sinks via 15N Relaxation Dynamics in Metronidazoles Hyperpolarized via SABRE-SHEATH.” Chemical Communications 56, no. 64 (2020): 9098–9101.

https://doi.org/10.1039/D0CC03994B

15N spin–lattice relaxation dynamics in metronidazole-15N3 and metronidazole-15N2 isotopologues are studied for rational design of 15N-enriched biomolecules for signal amplification by reversible exchange in microtesla fields. 15N relaxation dynamics mapping reveals the deleterious effects of interactions with the polarization transfer catalyst and a quadrupolar 14N nucleus within the spin-relayed 15N–15N network.

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