Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis

Grootveld, Martin, Benita Percival, Miles Gibson, Yasan Osman, Mark Edgar, Marco Molinari, Melissa L. Mather, Federico Casanova, and Philippe B. Wilson. “Progress in Low-Field Benchtop NMR Spectroscopy in Chemical and Biochemical Analysis.” Analytica Chimica Acta 1067 (August 2019): 11–30.

https://doi.org/10.1016/j.aca.2019.02.026

The employment of spectroscopically-resolved NMR techniques as analytical probes have previously been both prohibitively expensive and logistically challenging in view of the large sizes of high-field facilities. However, with recent advances in the miniaturisation of magnetic resonance technology, low-field, cryogen-free “benchtop” NMR instruments are seeing wider use. Indeed, these miniaturised spectrometers are utilised in areas ranging from food and agricultural analyses, through to human biofluid assays and disease monitoring. Therefore, it is both intrinsically timely and important to highlight current applications of this analytical strategy, and also provide an outlook for the future, where this approach may be applied to a wider range of analytical problems, both qualitatively and quantitatively. © 2019 Elsevier B.V. All rights reserved.

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