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DNP-NMR Literature Blog

Get up-to-date articles about dynamic nuclear polarization enhanced NMR spectroscopy
(DNP-NMR) and related terahertz technology from scientific journals. A free resource courtesy of Bridge12.

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Nuclear spin-hyperpolarization generated in a flavoprotein under illumination: experimental field-dependence and theoretical level crossing analysis

Ding, Yonghong, Alexey S. Kiryutin, Alexandra V. Yurkovskaya, Denis V. Sosnovsky, Renad Z. Sagdeev, Saskia Bannister, Tilman Kottke, et al. “Nuclear Spin-Hyperpolarization Generated in a Flavoprotein under Illumination: Experimental Field-Dependence and Theoretical Level Crossing Analysis.” Scientific Reports 9, no. 1 (December 2019): 18436.

The solid-state photo-chemically induced dynamic nuclear polarization (photo-CIDNP) effect generates non-equilibrium nuclear spin polarization in frozen electron-transfer proteins upon illumination and radical-pair formation. The effect can be observed in various natural photosynthetic reaction center proteins using magic-angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy, and in a flavin-binding light-oxygen-voltage (LOV) domain of the blue-light receptor phototropin. In the latter system, a functionally instrumental cysteine has been mutated to interrupt the natural cysteineinvolving photochemistry allowing for an electron transfer from a more distant tryptophan to the excited flavin mononucleotide chromophore. We explored the solid-state photo-CIDNP effect and its mechanisms in phototropin-LOV1-C57S from the green alga Chlamydomonas reinhardtii by using fieldcycling solution NMR. We observed the 13C and, to our knowledge, for the first time, 15N photo-CIDNP signals from phototropin-LOV1-C57S. Additionally, the 1H photo-CIDNP signals of residual water in the deuterated buffer of the protein were detected. The relative strengths of the photo-CIDNP effect from the three types of nuclei, 1H, 13C and 15N were measured in dependence of the magnetic field, showing their maximum polarizations at different magnetic fields. Theoretical level crossing analysis demonstrates that anisotropic mechanisms play the dominant role at high magnetic fields.

Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized 13C-methylglyoxal #DNPNMR #dDNP

Shishmarev, Dmitry, Philip W. Kuchel, Guilhem Pagès, Alan J. Wright, Richard L. Hesketh, Felix Kreis, and Kevin M. Brindle. “Glyoxalase Activity in Human Erythrocytes and Mouse Lymphoma, Liver and Brain Probed with Hyperpolarized 13C-Methylglyoxal.” Communications Biology 1, no. 1 (December 2018): 232.

Methylglyoxal is a faulty metabolite. It is a ubiquitous by-product of glucose and amino acid metabolism that spontaneously reacts with proximal amino groups in proteins and nucleic acids, leading to impairment of their function. The glyoxalase pathway evolved early in phylogeny to bring about rapid catabolism of methylglyoxal, and an understanding of the role of methylglyoxal and the glyoxalases in many diseases is beginning to emerge. Metabolic processing of methylglyoxal is very rapid in vivo and thus notoriously difficult to detect and quantify. Here we show that 13C nuclei in labeled methylglyoxal can be hyperpolarized using dynamic nuclear polarization, providing 13C nuclear magnetic resonance signal enhancements in the solution state close to 5,000-fold. We demonstrate the applications of this probe of metabolism for kinetic characterization of the glyoxalase system in isolated cells as well as mouse brain, liver and lymphoma in vivo.

[NMR] Solid-state NMR specialist at EPFL

The Institute of Chemistry and Chemical Engineering at EPFL (ISIC; is currently looking for a full-time specialist in solid-state NMR for its NMR platform ( 

As solid-state NMR specialist, you will have the responsibility to advise and guide EPFL researchers wishing to characterize their samples by solid-state NMR. A major part of the work will be dedicated to the preparation and measurement of these samples.

You will be in charge of the solid-state spectrometers of the ISIC NMR platform (two 400 MHz routine spectrometers, and four research spectrometers at 400, 500 and 900 MHz able to work at low temperature (100 K), fast MAS (100 kHz) with possible coupling to DNP. 

The user pool is large and diverse, (chemistry, material sciences, life sciences, physics …), and we are thus looking for an open-minded, well organized and flexible person with a modern vision and knowledge of solid state NMR and service, who will integrate smoothly into our existing team.
Candidates should submit their application online before 15.01.2021.

More details on the position and the application process here: :
For additional information, please contact Dr Aurélien Bornet (NMR platform leader, or Prof. Sandrine Gerber (Responsible for ISIC Platforms,
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[NMR] Open Position of Research Engineer in Solid State NMR – TOTAL Research & Technology Feluy – Belgium

Position of Research Engineer in NMR

The Analytical Department of the Research Center of Feluy (Belgium) being part of the R&D of TOTAL is looking for a Research Engineer specialized in Solid State NMR for a fixed-term contract of 24 months leading to permanent contract.

Under the responsibility of the Structure, Functionality and Morphology Service Manager, the applicant mission will be to:

  • Design, conduct and implement developments in high resolution NMR to provide the key chemical information required by the R&D departments of TOTAL company in the field of materials for energy such as catalysts, polymers, batteries, etc… and in this way participate in the development of new products and resolution of problems encountered by customers or in the Business Units.
  • Evaluate and develop new methods and new equipments.
  • Adapt practices to customer requests and products.
  • Operate High Resolution Solid State NMR equipment.
  • Realize assays, analyze results, draw conclusions, make the necessary recommendations and draft synthetic documents
  • Ensure reliable analytical results,
  • Propose and follows works done with academics in her/his area of ​​competence,
  • Propose equipment investments, maintenance schedules, ensures the availability of machines and consumables,
  • Tutor trainees,

Required Profile:       PhD in chemistry or analytical science. HR SS NMR specialty on battery problematics.

Moreover, Knowledge or experience in High Resolution Liquid NMR and Low Field NMR as well as a background on Catalyst and/or Polymer domains would be highly appreciated

Specific abilities:

  • Great interpersonal skills
  • Project management
  • Strong written and oral communication skills in French and in English.
  • To have an analytical turn of mind
  • To work as a team

To join the NMR reference laboratory of Total R&D in a pluri-disciplinary analytical team, send a curriculum vitae and a motivation letter to:

Raffinage-ChimieDirection Recherche et Développement
Responsable du Service Structure, Fonctionnalité & Morphologie
Tél : +32 (0)64 51 41 18Fax : +32 (0)64 51 08
\"trait.jpg\" \"logo.jpg\"Total Research & Technology FeluyDépartement AnalyseZone Industrielle
B-7181 Feluy

TOTAL Classification: Restricted Distribution TOTAL – All rights reserved
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Challenges and perspectives in quantitative NMR

Giraudeau, Patrick. “Challenges and Perspectives in Quantitative NMR.” Magn. Reson. Chem., 2016, 9.

This perspective article summarizes, from the author’s point of view at the beginning of 2016, the major challenges and perspectives in the field of quantitative NMR. The key concepts in quantitative NMRare first summarized; then, themost recent evolutions in terms of resolution and sensitivity are discussed, as well as some potential future research directions in this field. A particular focus is made on methodologies capable of boosting the resolution and sensitivity of quantitative NMR, which could open application perspectives in fields where the sample complexity and the analyte concentrations are particularly challenging. These include multi-dimensional quantitative NMR and hyperpolarization techniques such as para-hydrogen-induced polarization or dynamic nuclear polarization. Because quantitative NMR cannot be dissociated from the key concepts of analytical chemistry, i.e. trueness and precision, the methodological developments are systematically described together with their level of analytical performance.

Zero-field nuclear magnetic resonance of chemically exchanging systems

Barskiy, Danila A., Michael C. D. Tayler, Irene Marco-Rius, John Kurhanewicz, Daniel B. Vigneron, Sevil Cikrikci, Ayca Aydogdu, et al. “Zero-Field Nuclear Magnetic Resonance of Chemically Exchanging Systems.” Nature Communications 10, no. 1 (December 2019): 3002.

Zero- to ultralow-field (ZULF) nuclear magnetic resonance (NMR) is an emerging tool for precision chemical analysis. In this work, we study dynamic processes and investigate the influence of chemical exchange on ZULF NMR J-spectra. We develop a computational approach that allows quantitative calculation of J-spectra in the presence of chemical exchange and apply it to study aqueous solutions of [15N]ammonium (15NHfl4 ) as a model system. We show that pH-dependent chemical exchange substantially affects the J-spectra and, in some cases, can lead to degradation and complete disappearance of the spectral features. To demonstrate potential applications of ZULF NMR for chemistry and biomedicine, we show a ZULF NMR spectrum of [2-13C]pyruvic acid hyperpolarized via dissolution dynamic nuclear polarization (dDNP). We foresee applications of affordable and scalable ZULF NMR coupled with hyperpolarization to study chemical exchange phenomena in vivo and in situations where high-field NMR detection is not possible to implement.

Hyperpolarized relaxometry based nuclear T1 noise spectroscopy in diamond

Ajoy, A., B. Safvati, R. Nazaryan, J. T. Oon, B. Han, P. Raghavan, R. Nirodi, et al. “Hyperpolarized Relaxometry Based Nuclear T1 Noise Spectroscopy in Diamond.” Nature Communications 10, no. 1 (December 2019): 5160.

The origins of spin lifetimes in quantum systems is a matter of importance in several areas of quantum information. Spectrally mapping spin relaxation processes provides insight into their origin and motivates methods to mitigate them. In this paper, we map nuclear relaxation in a prototypical system of 13C nuclei in diamond coupled to Nitrogen Vacancy (NV) centers over a wide field range (1 mT-7 T). Nuclear hyperpolarization through optically pumped NV electrons allows signal measurement savings exceeding million-fold over conventional methods. Through a systematic study with varying substitutional electron (P1 center) and 13C concentrations, we identify the operational relaxation channels for the nuclei at different fields as well as the dominant role played by 13C coupling to the interacting P1 electronic spin bath. These results motivate quantum control techniques for dissipation engineering to boost spin lifetimes in diamond, with applications including engineered quantum memories and hyperpolarized 13C imaging.

[NMR] Postdoc position → Hyperpolarization at the CRMN in Lyon #DNPNMR

Generating and Transporting Hyperpolarization for preclinical MRI

A Postdoctoral position is available working in the group of Prof. Sami Jannin HMRLab on a project funded by the European Research Council, at CRMN in the city of Lyon, France.
We are looking for highly motivated candidate with strong scientific background, independence, and who enjoy teamwork. For postdoctoral positions, you must hold a PhD in Chemistry, Physics or related disciplines. Skills in will be appreciated in Nuclear magnetic resonance and possibly Dynamic nuclear polarization.

The candidate will in particular:

o   Perform low temperature DNP experiments with a functional state-of-the-art Bruker prototype polarizer, using novel hyperpolarizing materials that are synthetized in our team and that extend the lifetime of hyperpolarized MRI tracers to days (see doi:10.1038/ncomms13975doi:10.1073/pnas.1407730111, poster  here, and videos here )o   Transport hyperpolarized molecules to the preclinical MRI facility agro-resonance with a newly developed hyperpolarization transport system, and participate together with the specialized MRI team of Jean-Marie Bonny to pre-clinical imaging experiments.

The position will be open until filled with a possible starting date January-March 2021 with a one-year time commitment required and a possibility for two-years extension. 

You can get directly in touch directly with for further details on the position, and submit your application via e-mail as a single PDF file including:
i)              a cover letter (explaining background and motivation),
ii)             your CV,
iii)            contact information of 2-3 references.

The Center for Very High Field NMR is one of the world’s leading magnetic resonance laboratories, located in the great city of Lyon, which is affiliated to the Lyon-1 University, the CNRS (French National Center for Scientific Research) and the Ecole Normale Supérieure de Lyon. The center is equipped with state-of-the-art NMR spectrometers (500 – 700 – 800 MHz, and the world\’s first 1 GHz spectrometer) with two state of the art dissolution-DNP machines. It hosts research groups of worldwide-recognized excellence.

 Sami Jannin 
Professor at the Lyon 1 University 
Deputy Director Centre de RMN à Très Hauts Champs 
5 rue de la Doua 
69100 Villeurbanne FRANCE 
Team Leader Hyperpolarized Magnetic Resonance Lab 
Head of Lyon 1 University ERC support program 
mobile: +33 6 67 90 77 52 
office: +33 4 37 42 35 27
 We are hosting HYP21 
the 6th Hyperpolarization Conference 
in Lyon 
 follow us on TwitterOrcid , and Publons 

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Photochemically induced dynamic nuclear polarization NMR on photosystem II: donor cofactor observed in entire plant #CIDNP

Janssen, Geertje J., Pavlo Bielytskyi, Denis G. Artiukhin, Johannes Neugebauer, Huub J. M. de Groot, Jörg Matysik, and A. Alia. “Photochemically Induced Dynamic Nuclear Polarization NMR on Photosystem II: Donor Cofactor Observed in Entire Plant.” Scientific Reports 8, no. 1 (December 2018): 17853.

The solid-state photo-CIDNP (photochemically induced dynamic nuclear polarization) effect allows for increase of signal and sensitivity in magic-angle spinning (MAS) NMR experiments. The effect occurs in photosynthetic reaction centers (RC) proteins upon illumination and induction of cyclic electron transfer. Here we show that the strength of the effect allows for observation of the cofactors forming the spin-correlated radical pair (SCRP) in isolated proteins, in natural photosynthetic membranes as well as in entire plants. To this end, we measured entire selectively 13C isotope enriched duckweed plants (Spirodela oligorrhiza) directly in the MAS rotor. Comparison of 13C photo-CIDNP MAS NMR spectra of photosystem II (PS2) obtained from different levels of RC isolation, from entire plant to isolated RC complex, demonstrates the intactness of the photochemical machinery upon isolation. The SCRP in PS2 is structurally and functionally very similar in duckweed and spinach (Spinacia oleracea). The analysis of the photo-CIDNP MAS NMR spectra reveals a monomeric Chl a donor. There is an experimental evidence for matrix involvement, most likely due to the axial donor histidine, in the formation of the SCRP. Data do not suggest a chemical modification of C-131 carbonyl position of the donor cofactor.

Post-Doctoral Position Opening – Sherwin Group: High-power arbitrary waveform generation for pulsed magnetic resonance at 240 GHz and above, with applications dependent on post-doc’s interest.

Find the complete job description here:

Background: Coherent manipulation of electron spins at magnetic fields above 7 T (frequencies above 200 GHz) is required for investigations of decoherence in potential quantum bits, excitations of strongly-correlated spin systems, spintronics, and the structure and dynamics of biological macromolecules. However, with current technology, it is exceedingly difficult to generate the sequences of high-power sub-THz pulses that are required for these studies. By “slicing” a sequence of pulses from the ~kW output of UCSB’s MM-wave Free-Electron Laser, we have made significant progress towards filling this technological gap, and have demonstrated the world’s first FEL-powered electron paramagnetic resonance (EPR) spectrometer at 240 GHz. The existing “pulse slicer” uses high-power doubled Nd:YAG lasers to drive Si wafers from the insulating (transmissive) state to the conducting (reflective) state. It occupies two optical tables and is not easily reproduced.

The project: In collaboration with Bridge12, a small company in the Boston area, we have recently been funded to develop a “compact pulse slicer for high-power sub-millimeter waves.” The goal is to leverage advances in inexpensive solid-state laser and semiconductor wafer-bonding technologies to demonstrate a pulse slicer that can eventually be commercialized and deployed for use with existing submillimeter wave sources called gyrotrons to enable pulsed EPR and pulsed dynamic nuclear polarization. The team includes highly-experienced Ph. D. level scientists at UCSB, Bridge12, in the ThorLabs Crystalline Mirror Coatings division.

The job: The successful post-doc will, in close collaboration with the team, develop the optics and electronics for both reflective and transmissive elements of the compact pulse slicer, model the carrier dynamics in the semiconductor switches, perform pulse slicing experiments, and compare performance with theoretical predictions. With the pulse slicer they develop, the post-doc will be encouraged to pursue a scientific direction they are interested in within the broad range of topics under investigation in the Sherwin group. After completion of the post-doctoral job, the post-doc will be well positioned for a wide range of career options, including in academia, industry, and government labs.

Requirements: Applicants must have a Ph. D. in Physics, Applied Physics, Materials, Electrical Engineering, Physical Chemistry, or a related field of science or engineering at the time of application. Experience with developing scientific instrumentation, numerical modeling of physical phenomena, and one or more of the methodologies used in this project (for example, optics, lasers, semiconductors, microwaves, magnetic resonance) is preferred.

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