DNP-NMR Spectroscopy

Low signal-to-noise ratios present a huge challenge in nuclear magnetic resonance (NMR) spectroscopy and cause long acquisition times. They can make even some experiments outright impractical because they would require an unrealistic amount of spectrometer time.

To solve this challenge, you can boost the NMR signal intensity with dynamic nuclear polarization (DNP-NMR). Suitable mostly for solid-state NMR experiments, the method uses terahertz waves to provide a boost in NMR signal intensities by several orders of magnitude; thus increasing the signal intensity and data acquisition rate in a NMR experiment dramatically.

Four different components are required for dynamic nuclear polarization: 1) A polarizing agents (typically a biradical), 2) A low-temperature NMR probe that allows irradiation of the sample with THz and RF power, 3) A transmission line that delivers the THz power from the source to the sample and 4) A THz source such as a gyrotron.


Bridge12 offers the required instrumentation to upgrade your new or existing NMR spectrometers to perform dynamic nuclear polarization (DNP) experiments. This can be a smart alternative to off-the-shelf DNP-NMR solutions with the potential of huge cost savings. A typical dynamic nuclear polarization upgrade of your existing NMR spectrometer requires the following terahertz components:

  • A Gyrotron to generate the terahertz waves for dynamic nuclear polarization experiments
  • Transmission Line to guide the terahertz waves from the source to your sample
  • DNP-NMR probe to perform low-temperature NMR experiments

We are happy to discuss the different options for upgrading or retrofitting your NMR spectrometer – just contact us. If you’re not quite ready to talk to us, feel free to read some of the articles in the Learn section.

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