Category Archives: press

Dynamic nuclear polarization with photoexcited triplet electrons in a glassy matrix

Tateishi, K., et al., Dynamic nuclear polarization with photoexcited triplet electrons in a glassy matrix. Angew Chem Int Ed Engl, 2013. 52(50): p. 13307-10.

http://www.ncbi.nlm.nih.gov/pubmed/24249595

NMR spectroscopy and MRI are powerful methods for the non-destructive analysis of microscopic structures inside bulk materials and human bodies. As a method to enhance their sensitivities, dynamic nuclear polarization (DNP) has attracted great attention. The intensity of a signal from nuclear spins is proportional to the spin polarization. In magnetic fields conventionally used for NMR spectroscopy and MRI, thermal polarization of nuclear spins at room temperature is in the order of 10􏰵5 or less. DNP is a means of transferring spin polarization from electrons to nuclei.[1] The thermal polarization of electron spins is 660 times larger than that of 1H spins, and therefore, DNP can enhance the 1H spin polarization (hence the sensitivity) by a factor of at most 660.

Press Release: NIH Funds Development of Integrated THz System, Making DNP-NMR Spectroscopy More Affordable

Press Release


NIH Funds Development of Integrated THz System, Making DNP-NMR Spectroscopy More Affordable

Bridge12’s SBIR Fast-Track Grant Will Eliminate Need for Second Superconducting Magnet, Greatly Reducing Cost for Dynamic Nuclear Polarization

Framingham, Mass. – September 27th, 2013 – Bridge12 Technologies, a leading provider of terahertz (THz) technology for applications in science, medicine, security, and defense, announces it secured Phase I of a National Institute of Health’s (NIH) small business innovation research (SBIR) fast-track grant totaling $1.2 million over 3 years for the development of an Integrated THz system for DNP-NMR spectroscopy that eliminates the need for a second superconducting magnet, reducing the cost of DNP-NMR instrumentation by more than $0.8 million per spectrometer. Dynamic Nuclear Polarization (DNP) can increase the sensitivity of a NMR experiment by several orders of magnitude, accelerating experiments that typically require weeks to complete in minutes.

Nuclear magnetic resonance (NMR) spectroscopy is used broadly across many disciplines, such as analytical chemistry, structural biology or drug discovery and scientists that are using NMR spectroscopy are often challenged by the low sensitivity of NMR, which slows down research and increases research costs. In recent years, Dynamic Nuclear Polarization (DNP) has proven to be highly successful in increasing sensitivity in solid-state NMR experiments, achieving enhancement factors of > 200 at 400 MHz (1H Larmor Frequency) corresponding to a factor of 40,000 in time savings. In other words, an experiment that typically requires days or weeks of signal averaging can be performed in minutes or hours. This significantly increased overall sensitivity will accelerate NMR experiments for analytical applications or the structural characterization of bio-macromolecules or catalyst surfaces.

To efficiently drive the DNP process, scientists require high-power, high-frequency THz sources such as gyrotrons that can generate sufficient THz power. As a result, a conventional DNP-NMR system requires two superconducting magnets: one for the NMR experiment and another for the gyrotron. This makes DNP systems extremely expensive. The new Bridge12 project is focused on the development of a novel DNP system based on a THz source that is integrated into the superconducting NMR magnet. This is possible because wide-bore NMR magnets provide sufficient space right above the NMR probe to integrate and operate the gyrotron source. This novel, innovative gyrotron tube is specifically designed for DNP applications, providing sufficient power and has adequate frequency tuning bandwidth to eliminate the superconducting sweep coil that is necessary in other DNP systems. Eliminating the second superconducting magnet can save research groups more than $ 0.8 million per spectrometer, making DNP a much more affordable method. Currently predominantly used in the academic domain, the invention will make DNP-NMR a realistic options for industry researchers. The first prototype probe will be designed to operate at an NMR spectrometer frequency of 400 MHz but the technology is expected to work at NMR frequencies above 600 MHz.

“In recent years DNP has become an important method to increase the sensitivity in a NMR experiment,” says Dr. Thorsten Maly, Bridge12 co-founder and principal investigator for the project. “However, the high costs are prohibitive, especially for young researchers to enter this exciting new research field. Eliminating the superconducting magnet for the gyrotron will greatly reduce the acquisition and operating costs of a DNP-NMR system.. This will make DNP-NMR more affordable, especially for young-investigators/scientists entering the field. DNP is a young research field, so putting instrumentation within economic reach is important to enable research and increase the pace of innovation.”

“Gyrotrons were initially developed for heating plasma in nuclear fusion experiments, which requires megawatts of millimeter wave power and gyrotrons that are currently used in DNP-NMR spectroscopy are often downscaled versions of these devices. However, such high levels of power are not necessary for DNP-NMR,” says Dr. Jagadishwar Sirigiri, a Bridg12 founder and principal investigator for the project. “For this project we took a fresh new look at all components required in the DNP-NMR experiment. This allowed us to develop a novel concept for a gyrotron tube, specifically designed for DNP which will lead to more cost-effective system. ”

Phase I of this SBIR fast-track grant was awarded from the National Institute of General Medical Sciences (NIGMS), part of the National Institute of Health (NIH), in the amount of US$ 198,888 over a one-year period. The complete budget for the combined Phase I and II is 1.2 Million US$ over a period of 3 years.

About Bridge12

Bridge12 Technologies develops terahertz technology for applications in science, medicine, security and defense. Overcoming current technology barriers, the company closes the ‘terahertz gap’ with compact sources that are powerful, efficient, and rapidly deployable. Bridge12 Technologies’ solutions help accelerate scientific research, protect national security, and fight terminal diseases.

Bridge12 is a high-tech start-up founded by former scientists of the Massachusetts Institute of Technology (MIT). Its scientific team has several decades of combined expertise in high-frequency terahertz (THz) sources such as gyrotrons, microwave technology, and magnetic resonance spectroscopy. The executive team combines know-how of over 3 decades in project management, information technology, health care, and consumer products. For more information, visit www.bridge12.com.

###

Media Contact Information

Dr. Thorsten Maly
Director, Bridge12 Technology Inc.
Phone: +1 (617) 615-9332
Email: tmaly@bridge12.com

Press Release: NIH Funds Development of Integrated THz System, Making DNP-NMR Spectroscopy More Affordable

Press Release


NIH Funds Development of Integrated THz System, Making DNP-NMR Spectroscopy More Affordable

Bridge12’s SBIR Fast-Track Grant Will Eliminate Need for Second Superconducting Magnet, Greatly Reducing Cost for Dynamic Nuclear Polarization

Framingham, Mass. – September 27th, 2013 – Bridge12 Technologies, a leading provider of terahertz (THz) technology for applications in science, medicine, security, and defense, announces it secured Phase I of a National Institute of Health’s (NIH) small business innovation research (SBIR) fast-track grant totaling $1.2 million over 3 years for the development of an Integrated THz system for DNP-NMR spectroscopy that eliminates the need for a second superconducting magnet, reducing the cost of DNP-NMR instrumentation by more than $0.8 million per spectrometer. Dynamic Nuclear Polarization (DNP) can increase the sensitivity of a NMR experiment by several orders of magnitude, accelerating experiments that typically require weeks to complete in minutes.

Nuclear magnetic resonance (NMR) spectroscopy is used broadly across many disciplines, such as analytical chemistry, structural biology or drug discovery and scientists that are using NMR spectroscopy are often challenged by the low sensitivity of NMR, which slows down research and increases research costs. In recent years, Dynamic Nuclear Polarization (DNP) has proven to be highly successful in increasing sensitivity in solid-state NMR experiments, achieving enhancement factors of > 200 at 400 MHz (1H Larmor Frequency) corresponding to a factor of 40,000 in time savings. In other words, an experiment that typically requires days or weeks of signal averaging can be performed in minutes or hours. This significantly increased overall sensitivity will accelerate NMR experiments for analytical applications or the structural characterization of bio-macromolecules or catalyst surfaces.

To efficiently drive the DNP process, scientists require high-power, high-frequency THz sources such as gyrotrons that can generate sufficient THz power. As a result, a conventional DNP-NMR system requires two superconducting magnets: one for the NMR experiment and another for the gyrotron. This makes DNP systems extremely expensive. The new Bridge12 project is focused on the development of a novel DNP system based on a THz source that is integrated into the superconducting NMR magnet. This is possible because wide-bore NMR magnets provide sufficient space right above the NMR probe to integrate and operate the gyrotron source. This novel, innovative gyrotron tube is specifically designed for DNP applications, providing sufficient power and has adequate frequency tuning bandwidth to eliminate the superconducting sweep coil that is necessary in other DNP systems. Eliminating the second superconducting magnet can save research groups more than $ 0.8 million per spectrometer, making DNP a much more affordable method. Currently predominantly used in the academic domain, the invention will make DNP-NMR a realistic options for industry researchers. The first prototype probe will be designed to operate at an NMR spectrometer frequency of 400 MHz but the technology is expected to work at NMR frequencies above 600 MHz.

“In recent years DNP has become an important method to increase the sensitivity in a NMR experiment,” says Dr. Thorsten Maly, Bridge12 co-founder and principal investigator for the project. “However, the high costs are prohibitive, especially for young researchers to enter this exciting new research field. Eliminating the superconducting magnet for the gyrotron will greatly reduce the acquisition and operating costs of a DNP-NMR system.. This will make DNP-NMR more affordable, especially for young-investigators/scientists entering the field. DNP is a young research field, so putting instrumentation within economic reach is important to enable research and increase the pace of innovation.”

“Gyrotrons were initially developed for heating plasma in nuclear fusion experiments, which requires megawatts of millimeter wave power and gyrotrons that are currently used in DNP-NMR spectroscopy are often downscaled versions of these devices. However, such high levels of power are not necessary for DNP-NMR,” says Dr. Jagadishwar Sirigiri, a Bridg12 founder and principal investigator for the project. “For this project we took a fresh new look at all components required in the DNP-NMR experiment. This allowed us to develop a novel concept for a gyrotron tube, specifically designed for DNP which will lead to more cost-effective system. ”

Phase I of this SBIR fast-track grant was awarded from the National Institute of General Medical Sciences (NIGMS), part of the National Institute of Health (NIH), in the amount of US$ 198,888 over a one-year period. The complete budget for the combined Phase I and II is 1.2 Million US$ over a period of 3 years.

About Bridge12

Bridge12 Technologies develops terahertz technology for applications in science, medicine, security and defense. Overcoming current technology barriers, the company closes the ‘terahertz gap’ with compact sources that are powerful, efficient, and rapidly deployable. Bridge12 Technologies’ solutions help accelerate scientific research, protect national security, and fight terminal diseases.

Bridge12 is a high-tech start-up founded by former scientists of the Massachusetts Institute of Technology (MIT). Its scientific team has several decades of combined expertise in high-frequency terahertz (THz) sources such as gyrotrons, microwave technology, and magnetic resonance spectroscopy. The executive team combines know-how of over 3 decades in project management, information technology, health care, and consumer products. For more information, visit www.bridge12.com.

###

Media Contact Information

Dr. Thorsten Maly
Director, Bridge12 Technology Inc.
Phone: +1 (617) 615-9332
Email: tmaly@bridge12.com

New SBIR award to Bridge12 – NIH Funds Development of THz resonator for solid-state DNP-NMR Probes

Press Release

NIH Funds Development of THz resonator for solid-state DNP-NMR Probes

SBIR Grant Awarded to Bridge12 for Dynamic Nuclear Polarization


Framingham, Mass. – July 18th, 2013 – Bridge12 Technologies, a leading provider of terahertz (THz) technology for applications in science, medicine, security, and defense, announces it has received a National Institute of Health’s small business innovation research (SBIR) grant for the development of a THz resonator for solid-state DNP-NMR probes. Dynamic Nuclear Polarization (DNP) can increase the sensitivity of a NMR experiment by several orders of magnitude, accelerating experiments that typically require weeks to complete in minutes.


Nuclear magnetic resonance (NMR) spectroscopy is used broadly across many disciplines, such as analytical chemistry, structural biology or drug discovery and scientists that are using NMR are often challenged by the low sensitivity of NMR, which slows down research and increases research costs.

In recent years, Dynamic Nuclear Polarization (DNPhas proven to be vastly successful in increasing sensitivity in solid-

state NMR experiments, achieving enhancement factors of > 180 at 400 MHz (1Larmor Frequency) corresponding to a factor of 32,400 in time savings. In other words, an experiment that would otherwise run for three weeks can be performed in less than a minute. This significantly increased overall sensitivity accelerates experiments for analytical applications of NMR spectroscopy as well as the structural characterization of bio-macromolecules or pharmaceutical drug discovery.

New SBIR award to Bridge12 – NIH Funds Development of THz resonator for solid-state DNP-NMR Probes

Press Release

NIH Funds Development of THz resonator for solid-state DNP-NMR Probes

SBIR Grant Awarded to Bridge12 for Dynamic Nuclear Polarization


Framingham, Mass. – July 18th, 2013 – Bridge12 Technologies, a leading provider of terahertz (THz) technology for applications in science, medicine, security, and defense, announces it has received a National Institute of Health’s small business innovation research (SBIR) grant for the development of a THz resonator for solid-state DNP-NMR probes. Dynamic Nuclear Polarization (DNP) can increase the sensitivity of a NMR experiment by several orders of magnitude, accelerating experiments that typically require weeks to complete in minutes.


Nuclear magnetic resonance (NMR) spectroscopy is used broadly across many disciplines, such as analytical chemistry, structural biology or drug discovery and scientists that are using NMR are often challenged by the low sensitivity of NMR, which slows down research and increases research costs.

In recent years, Dynamic Nuclear Polarization (DNPhas proven to be vastly successful in increasing sensitivity in solid-

state NMR experiments, achieving enhancement factors of > 180 at 400 MHz (1Larmor Frequency) corresponding to a factor of 32,400 in time savings. In other words, an experiment that would otherwise run for three weeks can be performed in less than a minute. This significantly increased overall sensitivity accelerates experiments for analytical applications of NMR spectroscopy as well as the structural characterization of bio-macromolecules or pharmaceutical drug discovery.

NIH Funds Development of Solution-State DNP-NMR Probe

Press Release

NIH Funds Development of Solution-State DNP-NMR Probe 

Second SBIR Grant Awarded to Bridge12 for Dynamic Nuclear Polarization 

Framingham, Mass. – August 13th, 2012 – Bridge12 Technologies, a leading provider of terahertz (THz) technology for applications in science, medicine, security, and defense, announces it has received the National Institute of Health’s first small business innovation research (SBIR) grant for the development and commercialization of a solution-state DNP-NMR probe.

Dynamic Nuclear Polarization (DNP) can increase the sensitivity of an NMR experiment by several orders of magnitude, accelerating experiments that typically require weeks to complete in minutes. Unlike cryo-probes, which typically only yield a sensitivity increase of a factor of 3 or 4, the enhancements that are available through DNP are much larger (> 40). This significantly increased overall sensitivity accelerates experiments for analytical applications of NMR spectroscopy as well as the structural characterization of bio-macromolecules or pharmaceutical drug discovery.

Nuclear magnetic resonance (NMR) spectroscopy is used broadly across many disciplines, such as analytical chemistry, structural biology or drug discovery. Scientists using NMR are challenged by the low sensitivity of NMR, which slows down research and increases research costs. Currently, the only commercially available options to increase sensitivity are cryo-probes, which typically yield a sensitivity improvement of no more than a factor of 4. In contrast, the technique of Dynamic Nuclear Polarization (DNP) has proven to be vastly more successful in increasing sensitivity in both solid- and solution-state NMR experiments, showing improvements of more than a factor of 40 (400 MHz, 1H Larmor Frequency). The new Bridge12 research is focused on responding to this demand because researchers currently cannot take advantage of these enhancements due to the lack of commercially available DNP probes. 

The first prototype will be designed to operate at an NMR spectrometer frequency of 300 MHz but the technology is expected to work at NMR frequencies even above 600 MHz. The proposed probe can be retrofitted to existing NMR spectrometers, therefore preserving the significant investments in existing NMR platforms, and making the benefits of DNP-enhanced NMR spectroscopy available to a larger community. 

The successful development of this technology will enable the rapid proliferation of DNP-enhanced solution-state NMR spectroscopy for structural biology, pharmaceutical research, and analytical chemistry. 

“The biggest challenge of bringing the benefits of DNP to solution-state NMR spectroscopy is the extreme sample heating caused by the microwave/THz irradiation” says Dr. Thorsten Maly, a Bridge12 co-founder and principal investigator for the project. “At least two academic groups are currently developing microwave/THz resonators to overcome these heating problems and their approaches are based on conventional high-field EPR resonators that typically have very poor filling factors. At Bridge12, we have developed a novel dielectric THz resonator that is compatible with current high-resolution, solution-state NMR probe designs, which is expected to accommodate sample volumes of several microliters.” 

“Sensitivity has always been a major problem in NMR spectroscopy and DNP has more than proven itself in academic research, but the industry still lacks turn-key instrumentation,” says Dr. Jagadishwar Sirigiri, a Bridge12 founder and principal investigator for the project. “Through the use of DNP-NMR, researchers can increase the sensitivity of a NMR experiment by more than factor 40, breaking new ground and reducing experiment costs at the same time. We want to make DNP available to a larger community to fuel ideas that solve today’s pressing issues in analytical chemistry, structural biology, drug research, and other areas.” 

The SBIR grant was awarded from the National Institute of General Medicine (NIGMS), part of the National Institute of Health (NIH), in the amount of US$ 197,717 over a one-year period. 

About Bridge12 

Bridge12 Technologies develops terahertz technology for applications in science, medicine, security and defense. Overcoming current technology barriers, the company closes the ‘terahertz gap’ with compact sources that are powerful, efficient, and rapidly deployable. Bridge12 Technologies’ solutions help accelerate scientific research, protect national security, and fight terminal diseases. 

Bridge12 is a high-tech start-up founded by former scientists of the Massachusetts Institute of Technology (MIT). Its scientific team has over a decade of expertise in high-frequency terahertz (THz) sources such as gyrotrons, microwave technology, and magnetic resonance spectroscopy. The executive team combines know-how of over 3 decades in project management, information technology, health care, and consumer products. For more information, visit www.bridge12.com

### 

Media Contact Information

Dr. Thorsten Maly
Director, Bridge12 Technology Inc.
Phone: +1 (617) 615-9332
Email: tmaly@bridge12.com

NIH Funds Development of Solution-State DNP-NMR Probe

Press Release

NIH Funds Development of Solution-State DNP-NMR Probe 

Second SBIR Grant Awarded to Bridge12 for Dynamic Nuclear Polarization 

Framingham, Mass. – August 13th, 2012 – Bridge12 Technologies, a leading provider of terahertz (THz) technology for applications in science, medicine, security, and defense, announces it has received the National Institute of Health’s first small business innovation research (SBIR) grant for the development and commercialization of a solution-state DNP-NMR probe.

Dynamic Nuclear Polarization (DNP) can increase the sensitivity of an NMR experiment by several orders of magnitude, accelerating experiments that typically require weeks to complete in minutes. Unlike cryo-probes, which typically only yield a sensitivity increase of a factor of 3 or 4, the enhancements that are available through DNP are much larger (> 40). This significantly increased overall sensitivity accelerates experiments for analytical applications of NMR spectroscopy as well as the structural characterization of bio-macromolecules or pharmaceutical drug discovery.

Nuclear magnetic resonance (NMR) spectroscopy is used broadly across many disciplines, such as analytical chemistry, structural biology or drug discovery. Scientists using NMR are challenged by the low sensitivity of NMR, which slows down research and increases research costs. Currently, the only commercially available options to increase sensitivity are cryo-probes, which typically yield a sensitivity improvement of no more than a factor of 4. In contrast, the technique of Dynamic Nuclear Polarization (DNP) has proven to be vastly more successful in increasing sensitivity in both solid- and solution-state NMR experiments, showing improvements of more than a factor of 40 (400 MHz, 1H Larmor Frequency). The new Bridge12 research is focused on responding to this demand because researchers currently cannot take advantage of these enhancements due to the lack of commercially available DNP probes. 

The first prototype will be designed to operate at an NMR spectrometer frequency of 300 MHz but the technology is expected to work at NMR frequencies even above 600 MHz. The proposed probe can be retrofitted to existing NMR spectrometers, therefore preserving the significant investments in existing NMR platforms, and making the benefits of DNP-enhanced NMR spectroscopy available to a larger community. 

The successful development of this technology will enable the rapid proliferation of DNP-enhanced solution-state NMR spectroscopy for structural biology, pharmaceutical research, and analytical chemistry. 

“The biggest challenge of bringing the benefits of DNP to solution-state NMR spectroscopy is the extreme sample heating caused by the microwave/THz irradiation” says Dr. Thorsten Maly, a Bridge12 co-founder and principal investigator for the project. “At least two academic groups are currently developing microwave/THz resonators to overcome these heating problems and their approaches are based on conventional high-field EPR resonators that typically have very poor filling factors. At Bridge12, we have developed a novel dielectric THz resonator that is compatible with current high-resolution, solution-state NMR probe designs, which is expected to accommodate sample volumes of several microliters.” 

“Sensitivity has always been a major problem in NMR spectroscopy and DNP has more than proven itself in academic research, but the industry still lacks turn-key instrumentation,” says Dr. Jagadishwar Sirigiri, a Bridge12 founder and principal investigator for the project. “Through the use of DNP-NMR, researchers can increase the sensitivity of a NMR experiment by more than factor 40, breaking new ground and reducing experiment costs at the same time. We want to make DNP available to a larger community to fuel ideas that solve today’s pressing issues in analytical chemistry, structural biology, drug research, and other areas.” 

The SBIR grant was awarded from the National Institute of General Medicine (NIGMS), part of the National Institute of Health (NIH), in the amount of US$ 197,717 over a one-year period. 

About Bridge12 

Bridge12 Technologies develops terahertz technology for applications in science, medicine, security and defense. Overcoming current technology barriers, the company closes the ‘terahertz gap’ with compact sources that are powerful, efficient, and rapidly deployable. Bridge12 Technologies’ solutions help accelerate scientific research, protect national security, and fight terminal diseases. 

Bridge12 is a high-tech start-up founded by former scientists of the Massachusetts Institute of Technology (MIT). Its scientific team has over a decade of expertise in high-frequency terahertz (THz) sources such as gyrotrons, microwave technology, and magnetic resonance spectroscopy. The executive team combines know-how of over 3 decades in project management, information technology, health care, and consumer products. For more information, visit www.bridge12.com

### 

Media Contact Information

Dr. Thorsten Maly
Director, Bridge12 Technology Inc.
Phone: +1 (617) 615-9332
Email: tmaly@bridge12.com

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