Category Archives: Postdoc Position

[NMR] Postdoctoral position at New York University (singlet states)

Postdoctoral position at New York University

(singlet states)

Department of Chemistry

Applications are solicited for an individual to be appointed as an postdoctoral associate under the supervision of Alexej Jerschow. The research will focus on the study of nuclear spin singlet state life times and singlet relaxation mechanisms, the development of efficient singlet/triplet conversion pulse sequences and methodology, as well as para-hydrogen induced polarization (PHIP).

Successful applicants must hold a Ph.D. degree in a related field. The ideal candidate will have strong experience in NMR spectrometer operation and pulse sequence development. Expertise in simulations and/or hardware would be beneficial as well.

Some relevant publications:

• Chem. Phys. Chem. 2016, in press,

http://dx.doi.org/10.1002/cphc.201600663

• J. Magn. Reson. 2017, 284, 1-7

https://doi.org/10.1016/j.jmr.2017.09.005; free access link:

https://authors.elsevier.com/a/1Vkv~_OpItj~0r

• PCCP17, 2015, 24370 – 24375, http://dx.doi.org/10.1039/c5cp03716f

There is also an opportunity to be involved in other ongoing projects in the laboratory including in situ battery MRI (Nat Comm 9:1776, 2018,

http://dx.doi.org/10.1038/s41467-018-04192-x).

The lab is located in newly renovated facilities of the Molecular Nanoscience Center at NYU’s Washington Square Campus in the heart of Manhattan.

The initial appointment is for a year, with a possibility of renewal. Applications will be reviewed on a rolling basis, and candidates will be considered until the position is filled.

To be considered, all applicants must submit a cover letter summarizing research experience and specifying the interests in this position; a curriculum vitae (including a publication list); a statement of research interests; and two letters of reference. The application can be submitted through this link: https://apply.interfolio.com/70493.

Alexej Jerschow

Professor of Chemistry

Chemistry Department

New York University

100 Washington Square East

New York, NY 10003

ph: +1 212 998 8451

fax: +1 212 995 4475

alexej.jerschow@nyu.edu

https://wp.nyu.edu/jerschow/

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[NMR] solid-state NMR postdoc position available

Dear NMR community;

A postdoctoral position is available in my laboratory at UC Irvine (please see attached description.) The project involves developing and using multidimensional sequences for incorporating 2H into protein structure determination experiments in solids, using our unique quadruple-resonance MAS probe operating at 800 MHz. Anyone who is interested should email Rachel Martin (rwmartin@uci.edu). The formal application can be found on UCI’s website at https://recruit.ap.uci.edu/JPF05254. I will also be at the Alpine conference in Chamonix if any potential candidates who are attending the meeting would like to discuss the project with me.

Best,

Rachel Martin

DESCRIPTION

School of Physical Sciences

Department of Chemistry

Position: Postdoctoral Position – Solid-State NMR

A postdoctoral position is available at the University of California, Irvine in the area of protein structure determination by solid-state NMR, specifically of the aggregates of eye lens proteins found in cataract disease. The goal of this NIH-funded project is to develop and use advanced solid-state NMR methods for the study of complicated protein aggregates. The group has access to an 800 MHz instrument, equipped with solution-state and MAS probes, including a unique crossed-coil 1H/13C/2H/15N MAS probe purpose-built for these experiments. We also have two dedicated 500 MHz NMR instruments (one solids and one liquids), as well as a fully-equipped molecular biology

laboratory for sample preparation. The ideal candidate will be experienced in protein structure determination by MAS and interested in using novel instrumentation to solve biological problems.

The project supports solid-state NMR methods development and structure determination of wild-type human γS-crystallin in the transparent hydrogel state found in the healthy eye lens, as well as the aggregates formed by UV-light damaged proteins and cataract-related variants. The Martin group is experienced in preparation of crystallin proteins: isotopically labeled samples of the transparent hydrogel of the native crystallin and the aggregates associated with cataract have been prepared. As part of this project, new NMR methodology will be developed to investigate the structural factors related to γS-crystallin stability and solubility. Differential isotope labeling of peptide binders and variant crystallins will be used to identify specific residues involved in altered intermolecular interactions, followed by full structure determination of cataract aggregates. Extensive use will be made of deuterated samples and deuterium NMR in the context of multidimensional NMR experiments.

Candidates must have (or be about to earn) a Ph.D. in Chemistry, Physics, or a related discipline, and have experience solving protein structures using MAS NMR. Previous experience with pulse sequence development is desirable but not required.

Please apply online at https://recruit.ap.uci.edu/apply/JPF05254 with a cover letter that also describes your immediate and long-term research goals, a curriculum vitae including publications list, and names for three letters of reference (please do not solicit letters). Review of applications will begin on Oct 1, 2019 and will continue until the position is filled.

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

Rachel W. Martin

Professor of Chemistry

and Molecular Biology & Biochemistry

University of California, Irvine

rwmartin@uci.edu

probemonkey.com

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[NMR] Postdoctoral position in DNP-enhanced Magnetic Resonance #DNPNMR

Postdoctoral Researcher in DNP-enhanced Magnetic Resonance 

Barcelona, Spain

A postdoctoral research position is available starting from January 1st 2020 at the Institute for Bioengineering of Catalonia (IBEC), funded by an EU Horizon 2020 Future Emerging Technologies (H2020 FET-OPEN) grant. 

The position is fully funded for a period of up to 36 months.

The project we offer concerns real-time study of metabolism in engineered “organ-on-a-chip” tissue systems via hyperpolarized magnetic resonance. As part of our efforts to create non-invasive platforms for tailored drug testing, the successful candidate will be involved in the development of Carbon-13 hyperpolarization methods, as well as carrying out innovative work on the tissue engineering side of the project. 

Applicants should have a Ph.D. in engineering, physics, or chemistry. Previous experience in nuclear magnetic resonance or magnetic resonance imaging is necessary. Experience with 13C hyperpolarization, magnetic resonance hardware, data acquisition and signal/image processing is strongly favored. Knowledge of C++, Matlab, Python, and magnetic resonance spectrometer programming languages, will also be evaluated. Applicants should also have a strong track record of publications in peer-reviewed scientific journals and excellent communication skills.

Environment:

The Institute for Bioengineering of Catalonia (IBEC) is a research institute covering most bioengineering fields, from basic research to medical applications. IBEC is located at the Barcelona Science Park (PCB, www.pcb.ub.edu) in central Barcelona, and has strong connections with the nearby Bellvitge University Hospital (BUH). The researcher will have access to a commercial DNP instrument (3.35 T), and NMR spectrometers (60 MHz, 400 MHz, and 500 MHz 1H frequencies) in addition to clean room facilities, bio-laboratory space and computing equipment.

IBEC is also part of the Barcelona Institute of Science and Technology (BIST), a scientific foundation of seven of Catalonia’s research centres of excellence (CRG, IBEC, ICFO, ICIQ, ICN2, IFAE, IRB). The mission of BIST is to build new scientific collaborations among these centres, thus giving impulse to multidisciplinary projects to push ever further the frontiers of knowledge. Each BIST centre has reached a high level of excellence in its respective areas of expertise.

Contact: 

For informal inquiries about the position, please contact Dr. Irene Marco-Rius (imarco@ibecbarcelona.eu), Junior Leader fellow, Ramon laboratory, IBEC. 

Interested applicants should send the following materials: (1) a cover letter detailing research interests, (2) a curriculum vitae, (3) letters of recommendation from two referees.

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NYU Provost’s Postdoctoral Fellowship Program

New York University’s Provost’s postdoctoral fellowship/‘faculty fellow’

We are writing to identify suitable candidates for an New York University’s Provost’s postdoctoral fellowship award for an appointment as ‘faculty fellow’. The program provides fellows with faculty mentoring, professional development, and academic networking opportunities. The ultimate goal of the program is for participants to join the ranks of faculty at competitive institutions.

Fellows will be appointed as “Assistant Professor/Faculty Fellow” and will receive a $42,000 nine-month salary; an annual housing allowance ($20,000); a research allowance ($2,000); and reimbursement for one-time relocation fees (up to $3,000). Such compensation will be subject to appropriate taxation. The University also provides a benefits package, including medical and dental coverage.

The fellowship starts in September 2020 and applications are due by Oct 28, 2019.

New York University is located in the heart of Manhattan (Greenwich Village).

Research opportunities in the Department of Chemistry include work in areas of materials science and chemical biology. NMR-related projects are available in the department in the groups of Nate Traaseth and Alexej Jerschow and involve research on membrane protein transporters in drug resistance, receptor tyrosine kinases, solid-state NMR methodology, the study of singlet state lifetimes, para-hydrogen induced polarization, MRI of batteries and battery materials.

Informal inquiries about NMR-related research opportunities can be sent to traaseth@nyu.edu, or alexej.jerschow@nyu.edu. Inquiries about the application process should be sent to the provost’s office. Additional information about this opportunity is available here: https://apply.interfolio.com/67543.

Equal Employment Opportunity Statement

For people in the EU, click here for information on your privacy rights under GDPR: www.nyu.edu/it/gdpr

New York University is an Equal Opportunity Employer. New York University is committed to a policy of equal treatment and opportunity in every aspect of its hiring and promotion process without regard to race, color, creed, religion, sex, pregnancy or childbirth (or related medical condition), sexual orientation, partnership status, gender and/or gender identity or expression, marital, parental or familial status, caregiver status, national origin, ethnicity, alienage or citizenship status, veteran or military status, age, disability, predisposing genetic characteristics, domestic violence victim status, unemployment status, or any other legally protected basis. Women, racial and ethnic minorities, persons of minority sexual orientation or gender identity, individuals with disabilities, and veterans are encouraged to apply for vacant positions at all levels.

Sustainability Statement

NYU aims to be among the greenest urban campuses in the country and carbon neutral by 2040. Learn more at nyu.edu/sustainability

Alexej Jerschow

Professor of Chemistry

Chemistry Department

New York University

100 Washington Square East

New York, NY 10003

ph: +1 212 998 8451

fax: +1 212 995 4475

alexej.jerschow@nyu.edu

https://wp.nyu.edu/jerschow/

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[NMR] Postdoc/PhD position in Fluidics for Hyperpolarized Metabolic Magnetic Resonance #DNPNMR

Center for Hyperpolarization in Magnetic Resonance invites applications for a PhD or Post-doc position in Fluidics for Hyperpolarized Metabolic Magnetic Resonance.

Center for Hyperpolarization in Magnetic Resonance (HYPERMAG) is a center of excellence funded by the Danish National Research Foundation. We are part of the Center for Magnetic Resonance (www.cmr.healthtech.dtu.dk) at the department of Health Technology and conduct research in metabolic MRI and NMR. Our research is conducted in collaboration with universities, hospitals and healthcare companies both nationally and internationally. Our main educational responsibility is within the BSc and MSc program in BioMedical Engineering in collaboration with the Faculty of Health Sciences, University of Copenhagen.

Our mission is to address basic scientific questions of hyperpolarization by Dynamic Nuclear Polarization (DNP) to enable new applications of Magnetic Resonance in the study of biochemical reactions in real-time in vivo and in vitro. The group has high-resolution NMR systems of various types (e.g. Agilent, RS2D and Magritek), several polarizers (home-built and Hypersense), a cell lab, chemistry lab and electronics labs. We are 20-25 researchers and support staff.

Responsibilities and tasks

You will be responsible for 

  • The development of a robust sample transfer system between the dDNP polarizer and NMR equipment. With the purpose to reproducibly conduct metabolite identification experiments (fast transfer of bulk samples) and to conduct tracer studies in cell suspension (transfer of substrates and mixing with cells/infusion of hyperpolarized substrate). In particularly to ensure fast, automated and efficient transfer and mixing of the cells with the hyperpolarized substrate.
  • Making the transfer and mixing system compatible with a bioreactor for longitudinal studies of cell cultures.
  • As a PhD student you will further be responsible to apply the integrated transfer, mixing and bioreactor system on specific biological systems.
  • As a Post doc you will be a key collaborator for the biological sub-group of HYPERMAG for the application of the integrated transfer, mixing and bioreactor system to longitudinal studies on various cell lines in other projects.

Qualifications

Candidates should hold a Master (PhD position) or PhD degree (postdoc position) within the field of analytical chemistry or equivalent.

  • Hands on experience with fluidics and mechanics such as HPLC systems
  • Core interest in development of technical solutions for biological research
  • Experience with NMR
  • Experience with cell studies
  • You are driven by pushing boundaries
  • You enjoy working with complex topics
  • You are motivated by both individual and team accomplishment

Approval and Enrolment (only relevant for PhD candidates)

The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the DTU PhD Guide

We offer

DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment

The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The PhD position is for 3 years. The postdoc position is for 2 years.

The work place is DTU Lyngby campus.

You can read more about career paths at DTU here

Further information

Further information may be obtained from Prof. Jan Ardenkjær-Larsen, tel.: +45 4525 3918.

You can read more about DTU Health Tech at www.healthtech.dtu.dk/english

Application procedure

Please submit your online application (Postdoc/PhD position in Fluidics for Hyperpolarized Metabolic Magnetic Resonance) no later than 15 September 2019 (local time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link \”Apply online\”, fill out the online application form, and attach all your materials in English in one PDF file. The file must include: 

  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • PhD diploma (if applying for a post-doc position)
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here – if applying for a PhD position)

Candidates may apply for a PhD position prior to obtaining their master\’s degree but cannot begin before having received it.

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

Jan Henrik Ardenkjær-Larsen

Professor and Section Head

Center for Magnetic Resonance

Technical University of Denmark 

Department of Health Technology

Ørsted Plads, bldg 349, office 126

DK – 2800 Kgs. Lyngby

Phone +45 45253918

Mobile +45 40272775

jhar@elektro.dtu.dk

hypermag.dtu.dk

cmr.elektro.dtu.dk

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[NMR] Postdoctoral position in biomolecular MAS-DNP in Grenoble, France #DNPNMR

Post-doctoral position in MAS-DNP for the study of bacterial cell wall at CEA / Univ. Grenoble Alpes (France)

Application deadline September 1st 

A post-doctoral position is available immediately for a period of 18 months (with possible extension) to work with Sabine Hediger and Gaël De Paëpe on developing MAS-DNP for the study of bacterial cell wall. More information about our group at CEA Grenoble / Univ. Grenoble Alpes and a list of recent publications can be found here: www.dnpgrenoble.net.

Context of the project:

For over 50 years, peptidoglycan has played a pivotal role in the development of antibacterial chemotherapy. In the hunt for new drugs, the biosynthetic pathways of this ubiquitous cell wall polymer have been deciphered and essential peptidoglycan-synthesizing enzymes identified as antibacterial targets with high potential. Focusing on the L,D-transpeptidation, a key cell-wall synthesis and maturation reaction, we will first study purified enzymes in interaction with peptidoglycan fragments and then move on to the study of the complete cell-wall synthesis machinery in bacterial cells during the cell maturation.

Project :

In this context, innovative spectroscopic approaches including MAS-DNP will be conducted to provide new tools for the investigation of protein interaction with the bacterial cell wall. This project aims at developing the available MAS-DNP technique in order to provide best spectral sensitivity and resolution for the investigation of the bacterial cell wall itself in extracted and entire cells, as well as possible interactions with proteins involved in L,D-transpeptidation. These developments will make use of state-of-the-art DNP methods and polarizing agents developed or under development in the lab, which hosts two 400 MHz MAS-DNP spectrometers.

Requirements and application: 

Applicants are expected to have a doctoral degree in liquid-state and/or solid-state biomolecular NMR spectroscopy. Knowledge about MAS-DNP will be considered as a plus. The successful candidate will be recruited for 18 months (with possible extension) and will benefit from an ANR postdoctoral fellowship. Deadline for application is end of August. Interested candidates are welcomed to send an email to both: sabine.hediger@cea.fr and gael.depaepe@cea.fr.

Grenoble is one of the major cities in Europe for research with a large international scientific community. In addition, Grenoble has a large international student population, is a very pleasant city to live in, and is known as the “Capital of the Alps” with easy access to great skiing and hiking. It’s also only 2 hours’ drive to the Mediterranean Sea, Italy, or Switzerland. Grenoble, Lyon, and Geneva airports are nearby and permit straightforward international travel.

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[NMR] Postdoctoral position at Miami University

Postdoctoral Position: EPR Spectroscopic Studies of Membrane Proteins

Miami University, Oxford, OH, USA

A Postdoctoral research position is available immediately to study the structural and dynamic properties of integral membrane proteins in the laboratory of Prof. Gary A. Lorigan in the Department of Chemistry and Biochemistry at Miami University in Ohio. The postdoctoral position is funded through a NIH MIRA R35 grant.

Candidates who are interested in studying the structural and dynamic properties of membrane proteins are encouraged to apply. Experience in two of the following areas is desirable: molecular biology and biochemistry of membrane proteins, protein purification, and EPR spectroscopy. 2 pulsed EPR spectrometers (X-band/Q-band) for DEER and ESEEM experiments, 2 CW-EPR spectrometers, and a 500 MHz solid-state NMR instrument are available for this project. Miami University is home to the Ohio Advanced EPR Lab (http://epr.miamioh.edu). Please send a CV and two letters of recommendation to: Professor Gary A. Lorigan, Department of Chemistry and Biochemistry, Miami University gary.lorigan@miamioh.edu. A Ph.D. in Chemistry/Biochemistry or related fields is required. Contact phone is 513-529-3338. 

Miami University, an Equal Opportunity/Affirmative Action employer, encourages applications from minorities, women, protected veterans and individuals with disabilities. Miami University prohibits harassment, discrimination and retaliation on the basis of sex/gender (including sexual harassment, sexual violence, sexual misconduct, domestic violence, dating violence, or stalking), race, color, religion, national origin (ancestry), disability, age (40 years or older), sexual orientation, gender identity, pregnancy, status as a parent or foster parent, military status, or veteran status in its recruitment, selection, and employment practices. Requests for all reasonable accommodations for disabilities related to employment should be directed to ADAFacultyStaff@miamioh.edu or 513-529-3560.

As part of the University’s commitment to maintaining a healthy and safe living, learning, and working environment, we encourage you to read Miami University’s Annual Security & Fire Safety Report at http://www.MiamiOH.edu/campus-safety/annual-report/index.html(http://www.miamioh.edu/campus-safety/annual-report/index.html), which contains information about campus safety, crime statistics, and our drug and alcohol abuse and prevention program designed to prevent the unlawful possession, use, and distribution of drugs and alcohol on campus and at university events and activities. This report also contains information on programs and policies designed to prevent and address sexual violence, domestic violence, dating violence, and stalking. Each year, email notification of this website is made to all faculty, staff, and enrolled students. Written notification is also provided to prospective students and employees. Hard copies of the Annual Security & Fire Safety Report may be obtained from the Miami University Police Department at (513) 529-2225.

Gary A. Lorigan

John W. Steube Professor 

Department of Chemistry and Biochemistry

Miami University

651 E. High St.

Oxford, Ohio 45056

Office: 137 Hughes Laboratories

Phone: (513) 529-3338

Fax: (513) 529-5715

e-mail: gary.lorigan@miamioh.edu

web: www.users.muohio.edu/lorigag/index.html

EPR facility: epr.muohio.edu

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Post-Doctoral Position characterizing functional amyloids #DNPNMR

A Post-Doctoral position is available immediately to study functional amyloid formation by Streptococcus mutans, particularly as it relates to biofilm development. The focus of this project is to characterize the ultrastructure and amyloid properties of the adhesion P1 and other amyloidogenic surface proteins utilizing solution NMR, DNP-enhanced solid state NMR, cryoelectron microscopy, and diffraction techniques to study their structure in fibrillar and nonfibrillar forms. Applicants should have a strong background in biomolecular NMR spectroscopy, molecular microbiology, and biochemistry with an emphasis on protein structure/dynamics/function. Experience with standard cloning and recombinant DNA methodologies, protein chemistry, chromatography, and heterologous protein expression and purification is necessary. Familiarity with techniques to evaluate protein-protein interactions, protein crystallization and X-ray diffraction methodologies, mass spectrometry, and electron microscopy will be given preference. Also desirable would be familiarity with assays to assess amyloid fibrillization including use of fluorescent dyes and spectral shift assays, Congo-red induced birefringence, confocal microscopy and immunogold electron microscopy.

NMR facilities include fifteen spectrometers located at UF and the National High Magnetic Field Laboratory ranging from 500-900 MHz, including a 600 MHz ssNMR instrument with DNP capabilities. Extensive facilities for protein production and purification, cryoelec­tron microscopy, x-ray crystallography, and high performance computing are in close proximity to the Brady and Long labs as part of the UF centers for structural biology and high performance computing.

A Ph.D. and English language proficiency are required. Salary is commensurate with experience and range follows NIH guidelines. This is a grant-funded position and is annually renewable based on the availability of research funds. Please contact Joanna R. Long (jrlong@ufl.edu) and L. Jeannine Brady (jbrady@dental.ufl.edu) at The University of Florida, Departments of Biochemistry & Molecular Biology and Oral Biology, respectively, with any questions. (http://biochem.med.ufl.edu/research/faculty/primary-faculty/joanna-long/ and http://www.dental.ufl.edu/Offices/Oral_Biology/faculty/Brady_Linda/).

The University of Florida is an Equal Opportunity Institution dedicated to building a culturally diverse and inclusive faculty and staff. The selection process will be conducted in accord with the provisions of Florida’s “Government in the Sunshine” and Public Records Laws.

Joanna R. Long, PhD

Professor of Biochemistry & Molecular Biology

Director, Advanced Magnetic Resonance Imaging & Spectroscopy Facility

Assoc. Director, National High Magnetic Field Laboratory

McKnight Brain Institute, LG-187

Box 100245

University of Florida

Gainesville, FL 32605

(352)294-8399

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[NMR] Postdoctoral position in biomolecular MAS-DNP in Grenoble, France #DNPNMR

Post-doctoral position in MAS-DNP for the study of bacterial cell wall at CEA / Univ. Grenoble Alpes (France)

A post-doctoral position is available immediately for a period of 18 months to work with Sabine Hediger and Gaël De Paëpe on developing MAS-DNP for the study of bacterial cell wall. More information about our group at CEA Grenoble / Univ. Grenoble Alpes and a list of recent publications can be found here: www.dnpgrenoble.net.

Context of the project:

For over 50 years, peptidoglycan has played a pivotal role in the development of antibacterial chemotherapy. In the hunt for new drugs, the biosynthetic pathways of this ubiquitous cell wall polymer have been deciphered and essential peptidoglycan-synthesizing enzymes identified as antibacterial targets with high potential. Focusing on the L,D-transpeptidation, a key cell-wall synthesis and maturation reaction, we will first study purified enzymes in interaction with peptidoglycan fragments and then move on to the study of the complete cell-wall synthesis machinery in bacterial cells during the cell maturation.

Project :

In this context, innovative spectroscopic approaches including MAS-DNP will be conducted to provide new tools for the investigation of protein interaction with the bacterial cell wall. This project aims at developing the available MAS-DNP technique in order to provide best spectral sensitivity and resolution for the investigation of the bacterial cell wall itself in extracted and entire cells, as well as possible interactions with proteins involved in L,D-transpeptidation. These developments will make use of state-of-the-art DNP methods and polarizing agents developed or under development in the lab, which hosts two 400 MHz MAS-DNP spectrometers.

Requirements and application:

Applicants are expected to have a doctoral degree in liquid-state and/or solid-state biomolecular NMR spectroscopy. Knowledge about MAS-DNP will be considered as a plus. The successful candidate will be recruited for 18 months and will benefit from an ANR postdoctoral fellowship. Deadline for application is end of August. Interested candidates are welcomed to send an email to: sabine.hediger@cea.fr

Grenoble is one of the major cities in Europe for research with a large international scientific community. In addition, Grenoble has a large international student population, is a very pleasant city to live in, and is known as the “Capital of the Alps” with easy access to great skiing and hiking. It’s also only 2 hours’ drive to the Mediterranean Sea, Italy, or Switzerland. Grenoble, Lyon, and Geneva airports are nearby and permit straightforward international travel.

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Postdoctoral researcher, Parahydrogen biosensors for hypersensitive NMR analysis

See also the application link: https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=00007645&lang=en

Postdoctoral researcher, Parahydrogen biosensors for hypersensitive NMR analysis

The University of Oulu in Northern Finland, with approximately 15000 students and 3000 employees, is an international, multidisciplinary research university with a rich pool of creative and intellectual talent. The strengths of the University are broad, multidisciplinary research interests, a modern research and study environment, and wide cooperation with international research and educational institutes (http://www.oulu.fi/english).

The postdoctoral position is in the field of nuclear magnetic resonance (NMR), in the following specific topic: Development of metal-free catalytic systems for parahydrogen-based NMR hyperpolarization techniques.

The position is located at the NMR Research Unit (http://cc.oulu.fi/~nmrwww), in the Faculty of Science. We are an internationally established, combined experimental and theoretical team of about 20 people, of which 50% with a PhD degree. We develop experimental, theoretical and computational research methods based on magnetic resonance phenomena and apply those methods to topical problems in molecular and materials sciences. Our particular strength is in the tight connection between state-of-the-art measurements and calculations. We have an open and encouraging working atmosphere and have a substantial track record in successful funding applications both at the Academy of Finland and in EU programmes. We are a key user of the NMR laboratory facility of the University of Oulu, furnished with six spectrometers (300-600 MHz) suited for an unusually broad variety of studies (wide range of nuclei, gas/liquid/solid, different sample sizes, imaging capabilities, diffusion probe, micro CryoProbe, remote detection, spin-exchange optical pumping/parahydrogen-induced/SABRE hyperpolarization), two low-field, mobile NMR spectrometers as well as nuclear magneto-optic instrumentation. CPU-intensive computational research is carried out mainly using the facilities of the national supercomputer centre (2300 TFlop/s total capacity). Local linux clusters belonging to the Finnish Grid and Cloud Infrastructure are used for high-throughput production calculations.

Subject field and description of the position

The position is a part of Academy Project “Parahydrogen biosensors for hypersensitive NMR analysis” provided by the Academy of Finland.

The research direction of the position is briefly described in the following: The project aims at development of metal-free activators of H2 molecules capable of producing nuclear spin hyperpolarization upon activation of parahydrogen, increasing NMR sensitivity by orders of magnitude. Typically, metal-containing activators/catalysts are used in parahydrogen-based hyperpolarization techniques. We develop more biogenic metal-free catalytic systems that can be used to create hypersensitive NMR biosensors for biomolecular monitoring.

The length of the position is two years. The starting date of the position is September 16, 2019, or as soon as possible thereafter.

A six-month trial period will be effective in the beginning of the two-year contract.

Required Qualifications and assessment

The successful applicant must have a completed PhD in physics, chemistry, materials science, or a related field. The applicants must show a visible scientific profile. Significant experience in experimental NMR spectroscopy and other physical methods of analysis are to be documented for this position. Strong skills in synthetic and experimental organic chemistry are valuable to the project. Experience in the application of computational methods for studies of chemical reactivity is considered as an advantage. The project requires computer experience in data analysis (Excel, Origin, Matlab).

Fluent English, good communication skills and good teamwork skills are required. Further, demonstrated potential in acquiring supplementary (extramural) funding, and teaching experience will be taken as a merit when choosing the scientist. When assessing the applicant’s qualifications, issues to be considered will include scientific publications, thesis supervision, activity in the scientific community, practical familiarity with the field in question, scientific work abroad, and other international activities.

As part of the NMR Research Unit, the duties also include supervising scientific research of BSc, MSc and PhD students as well participation in important research activities of the group. Participation in teaching within the physics curriculum and acquiring research funding are naturally expected.

Salary

The salary will be based on the levels 5-6 of the demand level chart for university–level teaching and research staff of Finnish universities. In addition, a salary component based on personal work performance will be paid (maximum of 50 % of the job-specific component). The salary is thus in practice roughly 3400–4000 € per month, depending on the appointee’s qualifications, experience and the progress in the research.

Application Procedure

The following documents must be attached to the application:

1) Brief curriculum vitae in English

2) List of publications in international peer-reviewed journals

3) Brief description of research merits

4) Brief (1-2 pages) research and action plan in English

5) Contact information of two persons whom may be asked to give a statement of the candidate

Applications, together with all relevant enclosures, should be submitted using electronic application form by September 1, 2019 23:59 (Finnish local time).

Interview

The top candidates for the posts may be interviewed and asked to present their plans for running the post successfully.

For further information regarding the filling of this post:

Dr. Vladimir Zhivonitko, NMR Research Unit, University of Oulu, tel. +358-41-495 7904, email: vladimir.zhivonitko(at)oulu.fi

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