Category Archives: Postdoc Position

Post-doc in hyperpolarized 129Xe MRI – CEA Saclay, France

From the Ampere Magnetic Resonance List:

A project untitled: « Polarized Xenon-MRI for diagnosis and follow up of Chest Tumors » is granted by the French programme « Projets de recherche dans le domaine de la physique, des mathématiques ou des sciences de l\’ingénieur appliqués au cancer ».

We are looking for a post-doctoral fellow for one year starting July 2014. The place is CEA-Saclay (25 km in the S-W of Paris).

Abstract

Diagnosis and treatment of early stages of non-small-cell lung cancer (NSCLC) could drastically modify the outcome in terms of disease-free and overall survival.

MRI offers several advantages owing to its low invasiveness, its harmlessness and its spatial in-depth resolution but suffers from poor sensitivity. Very few MRI methods are able to detect events at the air-liquid interface (i.e. lung epithelium), due to the low number of detectable atoms present and the strong local magnetic field inhomogeneity. Different strategies can be used to improve MRI detection threshold in lungs including the use of hyperpolarized gases such as 3He and 129Xe. These species can be detected at very low concentration thanks to the gain by several orders of magnitude in nuclear polarization. 

In the project with Institut Gustave Roussy (IGR) and CEA/DSV, we propose a new approach based on 129Xe MRI biosensors for the early diagnosis of NSCLC and follow up of treatment efficacy.

The candidate will belong to the team having in charge the NMR/MRI part. He/she must have a strong background in MRI, an experience of in vivo experiments, and some notions of spin hyperpolarization. The laboratory owns several high-field spectrometers and two home-built setups for optical pumping of noble gases, and has access to the high-field small animal MR imagers at NeuroSpin (40 meters apart).

Interested candidate must send a detailed curriculum vitae and a letter of motivation to : Patrick Berthault 

CEA Saclay

IRAMIS/NIMBE/UMR3299

PC #9

91191 Gif sur Yvette, France

patrick.berthault@cea.fr

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Open position: Post Doc specialist in MM and SUB-­‐MMW technologies (M/F)

Open position: Post Doc specialist in MM and SUB-MMW technologies (M/F)

EPFL/LPMN and SWISSto12 SA are now opening a position for Research and Development activities focused on Terahertz Technologies. The project funded by CTI/KTI aims at developing a new family of Planar Probes for Dynamic Nuclear Polarization Enhanced Nuclear Magnetic Resonance.


Introduction to the field of the project:

Nuclear Magnetic Resonance (NMR) is a widespread tool used for research in Chemistry, Physics and

Biology. NMR Spectroscopy performances are greatly enhanced by Dynamic Nuclear Polarization (DNP). This technique involves irradiating samples with terahertz waves in order to excite the electron spin resonance. An innovative DNP-°©‐NMR probe based on a planar geometry has been recently patented by EPFL and CNR(I). Among other unprecedented features, this new piece of instrumentation (the probe) will allow the study of biological samples at room temperature.



Introduction to the commercial partner:

SWISSto12 is a private start‐up company, spin‐off of the Swiss Federal Institute of Technology in Lausanne, (EPFL). It aims at becoming a leading supplier of components and systems for Terahertz (THz) signal transmission. SWISSto12 holds exclusive licenses for patent applications owned by the EPFL, of which the company founders are the inventors. These patent applications cover manufacturing techniques that are the first ones to enable the production of efficient THz signal transmission components over the full THz frequency range. The strategic market position of SWISSto12 can only be developed and sustained through a strong and continuous R&D effort, allowing it to stay in tune with the latest developments. This effort is currently distributed over different projects aiming at reducing production costs, increasing product performances, seeking new solutions for THz signal transmission, as well as developing new products in the domain of Terahertz transmission and probing. Through collaborations with various companies and research institutions around the world SWISSto12 interacts with the key stakeholders for the development of future THz systems and components. The company is currently increasing its team to support its diverse R&D projects. 

Tasks :

  • Design and Numerical characterization of the probe.
  • Cold Tests on Sub‐Components on a brand‐new THz lab at LPMN
  • Probe Assembly
  • Experimental Validation.
  • Gyrotron DNP experiments for benchmark and training with an existing saddle‐coil probe
  • Interface with industrial partners and research institutions for R&D projects and collaborations.


Profile required for this position:

  • A PhD in physics, electrical engineering or electronics covering research on applied electromagnetism, or demonstrated equivalent experience;
  • Proven experience in laboratory tests and instrumentation development at a scientific R&D level, preferably targeting industrial applications;
  • Proven ability to perform high‐level analytical calculations and simulations using scientific software applications like Comsol, Matlab, Mathematica or equivalent;
  • Experience with dedicated electromagnetic or thermo‐mechanical simulation software is considered an advantage; 
  • Experience with supporting software applications for equipment design or laboratory tests, e.g. SolidWorks, Labview etc. is considered an advantage;
  • Interested, inquiring and innovative approach towards cutting edge R&D in electromagnetism;
  • Autonomous and proactive working style.
  • Communicating effectively, excellent relational skills and ability to work in a team;
  • Languages: Fluent in English and possibly in French.
  • Ability to coordinate working groups with different professional and cultural backgrounds.


Contract :

EPFL/LPMN offers a  three (3) contract to be started asap. An application containing a CV, a motivation letter, two reference letters and a copy of your diplomas and grades can be sent by mail to: jean‐philippe.ansermet@epfl.ch

Postdoc @ INAC (CEA / Grenoble university)

From the Ampere list:

Position: Researcher/Engineer at CEA INAC (Institute for Nanoscience and

Cryogenics)

Location: Grenoble/France

Field of research: Ultra Low Temperature Magic Angle Spinning Dynamic Nuclear

Polarization

Duration: 12 months, with possible extension upon results and funding.

We have an opening for a research/engineer position in ultra-low temperature MAS-DNP NMR at the Institute for Nanosciences and Cryogenics (CEA – Commissariat à l\’Energie Atomique et aux Energies Alternatives / University of Grenoble). 

Starting date: Beginning of 2014

The lab is equipped with a state of the art Bruker MAS-DNP system (400 MHz / 263 GHz) and is currently running a program to access MAS temperatures below 100 K using Helium spinning. Researchers/Engineers with a strong background or interest in Dynamic Nuclear Polarization / NMR methodology are welcomed to apply. PhD in solid-state NMR/ EPR or MRI is required. Experience with magnetic resonance hardware is heavily desired. A large part of the work will be conducted in close collaboration with Bruker Biospin.

Recent DNP papers from the group :

H. Takahashi et al., Angew. Chem. Intl. Ed. 51 (2012) 11766-11769. 

D. Lee et al., J. Am. Chem. Soc. 134 (2012) 18491-18494.

H. Takahashi et al., J. Am. Chem. Soc. 135 (2013) 5105-5110. 

H. Takahashi et al., Angew. Chem. Intl. Ed. 52 (2013) 6979-6982.

This fellowship is funded by the French National Research Agency. The initial

contract is for 12 months with the possibility of extension.

For further information regarding details of the work and of the appointment,

interested candidates should contact me directly at gael.depaepe@cea.fr.

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[NMR] Postdoctoral position at BMRZ / Goethe University Frankfurt

From the Ampere Magnetic Resonance List

Dear colleagues,

Applications are invited for a postdoctoral research position in Solid-state DNP Spectroscopy in the Emmy Noether research group led by Dr. Björn Corzilius at the Goethe University Frankfurt/Main, Germany (E13 TV-G-U, 100 %). The postdoctoral researcher will be placed at the seam between the BMRZ and the Institute of Physical and Theoretical Chemistry. The research group focuses on method development and basic research of DNP towards biomolecular applications.

To qualify, the applicant must hold a doctoral degree in chemistry, physics, biochemistry, or biophysics. The applicant must be ambitious and demonstrate a strong motivation and an appropriate background to help develop the proposed research area. Several years of research experience in magnetic resonance methods, especially in DNP, NMR, or EPR are required and should be supported by publications in high-ranking scientific journals and conference contributions. Good language skills in English are a crucial requirement.

The applicant will lead small research groups and work in a cutting-edge field situated at the seam between EPR and NMR and will therefore be able to build or extend an integral knowledge and expertise in the field of magnetic resonance. Experiments will be performed using state-of-the-art instrumentation at the BMRZ or external collaboration sites.

The successful candidate must have very good collaborative skills, have integrity and be flexible and capable of working in a structured and efficient way. The successful candidates should also be able to contribute to the innovative climate within the group.

Please send your relevant and comprehensive application material to Dr. Björn Corzilius: corzilius@em.uni-frankfurt.de.

The contract is fixed term, based on the regulations of the \”Wissenschaftszeitvertragsgesetz\” and the \”Hessische Hochschulgesetz\”. Initial appointment is for 1 year, with possible extension upon mutual agreement. The University is an equal opportunity employer and strongly encourages women to apply. In case of equal qualification, preference will be given to applicants with disabilities.

— 

Dr. Björn Corzilius

Emmy Noether Research Group Leader

Institute for Physical and Theoretical Chemistry,

Institute for Biophysical Chemistry

and Center for Biomolecular Magnetic Resonance (BMRZ)

Goethe University Frankfurt

Campus Riedberg

Building N140, Room 1

Max-von-Laue-Str. 7

60438 Frankfurt am Main

phone: +49-(0)69-798-29467

fax: +49-(0)69-798-29404

email: corzilius@em.uni-frankfurt.de

web: http://www.solidstateDNP.com

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[NMR] NMR Post-doc position at CEA Saclay, France

From the Ampere Magnetic Resonance List

Post-doc in hyperpolarized 129Xe MRI

A project untitled: « Polarized Xenon-MRI for diagnosis and follow up of Chest Tumors » is granted by the French programme « Projets de recherche dans le domaine de la physique, des mathématiques ou des sciences de l\’ingénieur appliqués au cancer ». We are looking for a post-doctoral fellow for one year starting January 2014. The place is CEA-Saclay (25 km in the S-W of Paris).

Abstract

Diagnosis and treatment of early stages of non-small-cell lung cancer (NSCLC) could drastically modify the outcome in terms of disease-free and overall survival.

MRI offers several advantages owing to its low invasiveness, its harmlessness and its spatial in-depth resolution but suffers from poor sensitivity. Very few MRI methods are able to detect events at the air-liquid interface (i.e. lung epithelium), due to the low number of detectable atoms present and the strong local magnetic field inhomogeneity. Different strategies can be used to improve MRI detection threshold in lungs including the use of hyperpolarized gases such as 3He and 129Xe. These species can be detected at very low concentration thanks to the gain by several orders of magnitude in nuclear polarization. Hyperpolarized xenon presents interesting properties for medical applications:

  • it is a non-toxic, freely diffusive tracer that crosses the cell membrane in some tens of milliseconds without polarization loss,
  • its spectral signature is strongly dependent on its environment,
  • it can be encapsulated in host molecules functionalized to target specific receptors (hereafter denoted biosensors).

In the project with Institut Gustave Roussy (IGR) and CEA/DSV, we propose a new approach based on 129Xe MRI biosensors for the early diagnosis of NSCLC and follow up of treatment efficacy.

The candidate will belong to the team having in charge the NMR/MRI part. He/she must have a strong background in MRI, an experience of in vivo experiments, and some notions of spin hyperpolarization. The laboratory owns several high-field spectrometers and two home-built setups for optical pumping of noble gases, and has access to the high-field small animal MR imagers at NeuroSpin (40 meters apart).

Interested candidate must send a detailed curriculum vitae and a letter of motivation to : 

Patrick Berthault 

CEA Saclay

IRAMIS/SIS2M/UMR3299

PC #9

91191 Gif sur Yvette, France

 Tel: (+33) 169 08 42 45

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[NMR] Postdoctoral position in NMR Hyperpolarisation

From the Ampere Magnetic Resonance List

The Korvink group at the Department of Microsystems Engineering, University of Freiburg, is inviting applications for a postdoctoral position in NMR hyperpolarisation. The research work is funded by an ERC project that targets novel NMR detector concepts in the broad area of miniaturised NMR. The successful candidate brings along research experience in para Hydrogen induced polarisation (PHiP). Any additional experience from the broad areas of NMR or MEMS will be of benefit.

The ideal candidate will be a recent PhD graduate with practical experience in PHiP. This may include as examples: catalyst design, substrate design, and/or pulse sequence development for efficient polarization transfer.  Responsibilities will include supervision of graduate students and leading PHiP activities within the context of the broader goals of the NMCEL project. As a highly interdisciplinary project, strong team and communication skills are imperative. 

The environment at IMTEK offers an outstanding scientific setting, including state-of-the-art microsystem fabrication facilities, an RF lab, and a dedicated 500 MHz wide-bore Bruker NMR spectrometer. The NMCEL team will be composed of 1-2 postdocs, 3-4 PhD students, and 3-4 masters students. The University of Freiburg offers several facilities suitable for supporting this project and is within one hour from Bruker headquarters in Karlsruhe for potential collaborative efforts.

The position is immediately available, at the E13 level for one year, and is extendable to a total duration of 2 years. Applications for the position should contain a motivational cover letter, a curriculum vitae, a publications list, and a copy of the applicant\’s most significant journal publication, preferably submitted via email as a single PDF file, to korvink@imtek.uni-freiburg.de. Applicants should be willing to travel to Freiburg for an interview. The university is currently seeking to increase the amount of female employees and is thus especially pleased to receive applications from qualified female candidates.

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Postdoc position (in vivo hyperpolarized 13C MR)

The University of Maryland School of Medicine is expanding its molecular imaging and interventional research capabilities with the addition of a Dynamic Nuclear Polarizer and High-Intensity Focused Ultrasound as part of the recently established Center for Integration of Metabolic Imaging and Therapeutics (CIMIT). This expansion is aimed to facilitate both basic science and clinical research by exploring novel molecular imaging agent based technologies for screening, early detection, and real-time image-guided interventions.

In this process a postdoctoral research fellowship position is available in the metabolic imaging group led by Dr. Dirk Mayer within the Magnetic Resonance Research Center (MRRC). The primary focus of the position will be on the development and evaluation of new in vivo acquisition methods for hyperpolarized 13C spectroscopic imaging in both animal models and humans. This is an exciting opportunity to work at one of the first sites that will do translational/clinical hyperpolarized 13C MRI/MRS.

The candidate should have a Ph.D. (or equivalent degree) in engineering, physics, physical chemistry, or similar fields. The ideal candidate has a background in NMR physics with particular emphasis on in vivo spectroscopy, data acquisition and processing. Experience in pulse sequence programming (ideally on a GE clinical scanner) is preferred. Knowledge of other computer languages, including C++, Matlab and IDL, and experience in performing small animal imaging experience is also desirable. Qualified applicants should also have a track record of first-author research papers published in peer-reviewed journals.

Interested individuals should send a letter detailing their research interests, an updated CV and contact information for at least two references to Dr. Dirk Mayer at dirk@umaryland.edu.

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Postdoctoral positions \”high field μMAS-DNP- NMR” and “Rapid melt DNP\”

Two postdoc positions for “DNP-enhanced NMR” both in the solid and liquid state are available immediately at the Solid State NMR group of the Institute of Molecules and Materials at the Radboud University of Nijmegen.

The solid NMR group at the Radboud University specializes in developing innovative technology to perform NMR spectroscopy on very small samples volumes both in the solid and in the liquid state. In the solid phase one can obtain ultrahigh proton decoupling fields (above 1 MHz RF field strength) improving the resolution to a few Hz at 20 T. Using on-chip NMR detection in a microfluidic environment we aim to resolve for example reaction pathways that are too fast for normal NMR. In this context we have started several new projects to improve the sensitivity by implementation of Dynamic Nuclear Polarization methods.

In collaboration with Agilent technologies and Bridge12 Technologies we are developing a solid state DNP setup at 600 MHz. The aim here is to combine the mMAS technology with DNP. The small sample size may allow lower temperatures and much higher microwave B1 field strengths.
In a second project we collaborate with various other groups in the university in an attempt to improve NMR detection sensitivity for the study of low concentration metabolites for example in screening for prostate cancer.

For both projects we are looking for enthusiastic postdocs that enjoys working in a challenging multidisciplinary environment. The postdoc candidate should hold a PhD in Physics or Chemistry. Hands-on experience in solid-state NMR or EPR spectroscopy with a track record in innovative method development is essential. Experience with DNP hardware is desirable. Actual building skills are highly appreciated. As most of the systems involve collaborations with other research groups, good communication skills are required.

The Institute for Molecules and Materials offers an exciting and stimulating research environment. State-of-the art solid-state NMR spectrometers operating at 300, 400, 600 and 850 MHz are available with the option to explore NMR options up to 1.3 GHz. 144 MHz Overhauser DNP spectrometer is operational, including options for rapid melt DNP, using an extended interaction klystron at 95 GHz as microwave source. A patented novel system for fast melt DNP is in operation. In this system the DNP takes place at cryogenic temperatures, while the NMR detection occurs in the liquid state using a highly efficient stripline NMR probe. A system for Overhauser DNP in the supercritical phase is under construction. A gyrotron source at 395 GHz will be installed in 2013.

The positions will be available for 2 years with the possibility of extension.

Please send a CV to Arno Kentgens (A.Kentgens@nmr.ru.nl) or Jan van Bentum (J.vanBentum@nmr.ru.nl) or contact us for more information.

Postdoctoral positions \”high field μMAS-DNP- NMR” and “Rapid melt DNP\”

Two postdoc positions for “DNP-enhanced NMR” both in the solid and liquid state are available immediately at the Solid State NMR group of the Institute of Molecules and Materials at the Radboud University of Nijmegen.

The solid NMR group at the Radboud University specializes in developing innovative technology to perform NMR spectroscopy on very small samples volumes both in the solid and in the liquid state. In the solid phase one can obtain ultrahigh proton decoupling fields (above 1 MHz RF field strength) improving the resolution to a few Hz at 20 T. Using on-chip NMR detection in a microfluidic environment we aim to resolve for example reaction pathways that are too fast for normal NMR. In this context we have started several new projects to improve the sensitivity by implementation of Dynamic Nuclear Polarization methods.

In collaboration with Agilent technologies and Bridge12 Technologies we are developing a solid state DNP setup at 600 MHz. The aim here is to combine the mMAS technology with DNP. The small sample size may allow lower temperatures and much higher microwave B1 field strengths.
In a second project we collaborate with various other groups in the university in an attempt to improve NMR detection sensitivity for the study of low concentration metabolites for example in screening for prostate cancer.

For both projects we are looking for enthusiastic postdocs that enjoys working in a challenging multidisciplinary environment. The postdoc candidate should hold a PhD in Physics or Chemistry. Hands-on experience in solid-state NMR or EPR spectroscopy with a track record in innovative method development is essential. Experience with DNP hardware is desirable. Actual building skills are highly appreciated. As most of the systems involve collaborations with other research groups, good communication skills are required.

The Institute for Molecules and Materials offers an exciting and stimulating research environment. State-of-the art solid-state NMR spectrometers operating at 300, 400, 600 and 850 MHz are available with the option to explore NMR options up to 1.3 GHz. 144 MHz Overhauser DNP spectrometer is operational, including options for rapid melt DNP, using an extended interaction klystron at 95 GHz as microwave source. A patented novel system for fast melt DNP is in operation. In this system the DNP takes place at cryogenic temperatures, while the NMR detection occurs in the liquid state using a highly efficient stripline NMR probe. A system for Overhauser DNP in the supercritical phase is under construction. A gyrotron source at 395 GHz will be installed in 2013.

The positions will be available for 2 years with the possibility of extension.

Please send a CV to Arno Kentgens (A.Kentgens@nmr.ru.nl) or Jan van Bentum (J.vanBentum@nmr.ru.nl) or contact us for more information.

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