Category Archives: Opportunity

PhD position -DNP/NMR- Solid State NMR Nijmegen

The department of Solid State NMR (group of Prof.dr. Arno Kentgens) is one of the partners of the so called \”UltraSense NMR\” project. 

*Large investment in UltraSense NMR for Analyses, screening and diagnostics.* 

**UltraSense NMR is a large research and development programme, sponsored by the EU and province, in cooperation between science and business. The project will be run by a large cooperation consortium between Radboud University Nijmegen: Institute of Molecules and Materials, UMC St. Radboud, University of Twente and 3 knowledge companies: Future Chemistry, Spinnovation Analytical and NovioGendix. 

Goal of the project is to develop hyperpolarisation equipment and strategies based on both physical (DNP) and chemical (pH2) principles. With the ultrasensitive microfluidic and continuous flow technology and equipment, we will be developing new diagnostic services and a molecular diagnostic test for prostate cancer. For this research programme we are looking for multidisciplined researchers, familiar with the field of physics, chemistry, biophysics, metabolic profiling, molecular diagnostics, who will be working closely togetherto generate a multidisciplinary research and development team responsible for generating the technology as well as the described prototype products. 

*VACANCIES* 

For the abovementioned developments we are looking for an enthusiastic PhD student who likes to be part of a multidisciplinary team in an internationally oriented environment:*. * 

* A PhD with experience in and enthusiasm for magnetic resonance. Knowledge of DNP is a benefit. The PhD will work on the development of optimized DNP technology allowing repetitive hyperpolarization with a focus on gaining both sensitivity and resolution in the context of metabolic profiling. 

For more information: http://www.ru.nl/physchem

If you\’re interested in this vacancy, please send an e-mail and cv to: m.dewith@science.ru.nl <mailto:m.dewith@science.ru.nl

— 

Marian de With 

Radboud University 

Institute for Molecules and Materials 

Secretary for depts. of Biophysical Chemistry and Solid State NMR 

Tel. +31 24 3652678 

Fax +31 24 3652112 

Web: www.ru.nl/physchem

Postdoctoral position in hyperpolarized singlet NMR

A postdoctoral position is available in the lab of Malcolm Levitt in Southampton, UK. The project is funded by the European Research Council and is for developing and applying hyperpolarized singlet NMR and MRI. The long lifetime of nuclear singlet states create obvious opportunities in combination with nuclear hyperpolarization. The lab is already well-equipped with NMR spectrometers: we are also acquiring a new solution NMR instrument, a DNP polarizer and microimaging hardware, under this project. We are particularly interested in working with a postdoc who is excited about the new experimental possibilities of this frontier technology and who has practical experience of one or more of the following topics: DNP, EPR/ESR, microwave technology, cryogenics, and MRI. The position may involve helping with the design and construction of novel hardware, so some experience of this is essential. 

The position is available for an initial period of 2 years. 

The position is open for applications at jobs.soton.ac.uk<http://jobs.soton.ac.uk/> under the code 107812EB, see 107812EB Postdoctoral Research Fellow in Nuclear Magnetic Resonance – Recruitment at the University of Southampton<https://jobs.soton.ac.uk/Vacancy.aspx?id=2076&forced=1

The application deadline is 30 April 2012.

Postdoctoral position in hyperpolarized singlet NMR

A postdoctoral position is available in the lab of Malcolm Levitt in Southampton, UK. The project is funded by the European Research Council and is for developing and applying hyperpolarized singlet NMR and MRI. The long lifetime of nuclear singlet states create obvious opportunities in combination with nuclear hyperpolarization. The lab is already well-equipped with NMR spectrometers: we are also acquiring a new solution NMR instrument, a DNP polarizer and microimaging hardware, under this project. We are particularly interested in working with a postdoc who is excited about the new experimental possibilities of this frontier technology and who has practical experience of one or more of the following topics: DNP, EPR/ESR, microwave technology, cryogenics, and MRI. The position may involve helping with the design and construction of novel hardware, so some experience of this is essential. 

The position is available for an initial period of 2 years. 

The position is open for applications at jobs.soton.ac.uk<http://jobs.soton.ac.uk/> under the code 107812EB, see 107812EB Postdoctoral Research Fellow in Nuclear Magnetic Resonance – Recruitment at the University of Southampton<https://jobs.soton.ac.uk/Vacancy.aspx?id=2076&forced=1

The application deadline is 30 April 2012.

5 Grants available for Chianti/INSTRUCT Workshop on Bio-NMR

5 GRANTS FROM INDUSTRIE SAPIO ARE AVAILABLE FOR YOUNG PEOPLE, COVERING 400€ OF THE REGISTRATION FEE. 

APPLY NOW! (deadline for submitting your CV is March 23rd) 

Registration deadline is March 31st, hurry up! 

—————————————————————————————————– 

12th Chianti/INSTRUCT Workshop on Bio-NMR – Electron and Nuclear Relaxation for Structural Biology 

Montecatini Terme (Pistoia), Italy, June 17-22, 2012 

The 12th Chianti/INSTRUCT Workshop on Bio-NMR – Electron and Nuclear Relaxation for Structural Biology will be held in Montecatini Terme, the ‘spa capital’ of Tuscany, from June 17th to 22nd 2012. In the tradition of the Chianti Workshops, electron and nuclear relaxation will be the central theme of the scientific program. A blend of novelty will come from an increased focus on biological systems, that fits in the frame of INSTRUCT. The Organizers trust that this will be a major event within the scientific community of magnetic resonance. The conference program will include invited talks and poster presentations and – as always at the Chianti Workshops – ample time will be allocated for interactions among the participants. 

Registration is open! Please visit the \’Registration\’ page on the website: 

http://www.cerm.unifi.it/chianti12/

5 Grants available for Chianti/INSTRUCT Workshop on Bio-NMR

5 GRANTS FROM INDUSTRIE SAPIO ARE AVAILABLE FOR YOUNG PEOPLE, COVERING 400€ OF THE REGISTRATION FEE. 

APPLY NOW! (deadline for submitting your CV is March 23rd) 

Registration deadline is March 31st, hurry up! 

—————————————————————————————————– 

12th Chianti/INSTRUCT Workshop on Bio-NMR – Electron and Nuclear Relaxation for Structural Biology 

Montecatini Terme (Pistoia), Italy, June 17-22, 2012 

The 12th Chianti/INSTRUCT Workshop on Bio-NMR – Electron and Nuclear Relaxation for Structural Biology will be held in Montecatini Terme, the ‘spa capital’ of Tuscany, from June 17th to 22nd 2012. In the tradition of the Chianti Workshops, electron and nuclear relaxation will be the central theme of the scientific program. A blend of novelty will come from an increased focus on biological systems, that fits in the frame of INSTRUCT. The Organizers trust that this will be a major event within the scientific community of magnetic resonance. The conference program will include invited talks and poster presentations and – as always at the Chianti Workshops – ample time will be allocated for interactions among the participants. 

Registration is open! Please visit the \’Registration\’ page on the website: 

http://www.cerm.unifi.it/chianti12/

PhD Position: Liquid state NMR experiments using a dedicated DNP NMR spectrometer based on a unique dual centre magnet

http://bit.ly/zGooYo

PhD Position: Liquid state NMR experiments using a dedicated DNP NMR spectrometer based on a unique dual centre magnet

The Dynamic Nuclear Polarisation (DNP) research group in Nottingham has designed and built a unique prototype DNP NMR facility based on a magnet with two iso-centres (3.4T and 9.4T)1. Hyperpolarised spin systems can be prepared by low temperature DNP (1.4K) at the 3.4T isocentre.2 Subsequently the sample is shuttled in solid state to the high field centre and rapidly dissolved by injection of small amounts of hot water. After this temperature jump the sample containing the highly polarised molecules is in liquid state at ambient temperature. The resulting signal enhancement compared to a thermally polarised sample which is used in conventional NMR can reach more than 10e4. 

This strategy makes it possible to detect either molecules at very low concentration or acquire their NMR signal in a single excitation even for 13C NMR. The project involves the investigation and improvement of several aspects of the experimental protocol: 

a) Testing novel radicals for their DNP properties. In particular, we are interested to developed strategies to increase the polarisation built-up time so that the overall waiting time for the generation of highly polarised samples can be substantially reduced. 

b) Testing novel ideas to decrease the volume of hot water needed to dissolve the cold sample. In particular, we will investigate the use of infrared lasers and microwaves to assist the melting and dissolution of the sample. 

c) Designing new ideas to mix samples in liquid state rapidly. The motivation is to use highly polarised ligands and monitor binding of these small molecules to larger macromolecules. 

d) Application of the improved strategy to study model ligand- protein systems to measure binding constants, first site of approach etc. 

This project requires an interest in experimental physics and offers training in a very wide range of techniques, including spin dynamics investigations, the testing of novel NMR hardware components and the application of novel NMR strategies to studies of biomolecular model systems. The DNP group in Nottingham currently carries out research in DNP NMR theory and hardwaredevelopment. It has recently received a prestigious Novel Technology Development award by the EPSRC that fund research with the objective to optimise the dissolution DNP NMR strategy. 

References: 

1. Leggett, J et al. Phys. Chem. Chem. Phys. 12(22), 5883-5892, 2010 

2. Ardenkjaer-Larson et al. 2003, Proc. Natl. Acad. Science USA, 100(18) 10158 

For further information contact Walter Köckenberger walter.kockenberger@nottingham.ac.uk or iMR.CDT@warwick.ac.uk. The Centre for Doctoral Training in Integrated Magnetic Resonance is a collaboration between researchers at the Universities of Warwick, St Andrews, Southampton, Aberdeen and Nottingham.

PhD Position: Liquid state NMR experiments using a dedicated DNP NMR spectrometer based on a unique dual centre magnet

http://bit.ly/zGooYo

PhD Position: Liquid state NMR experiments using a dedicated DNP NMR spectrometer based on a unique dual centre magnet

The Dynamic Nuclear Polarisation (DNP) research group in Nottingham has designed and built a unique prototype DNP NMR facility based on a magnet with two iso-centres (3.4T and 9.4T)1. Hyperpolarised spin systems can be prepared by low temperature DNP (1.4K) at the 3.4T isocentre.2 Subsequently the sample is shuttled in solid state to the high field centre and rapidly dissolved by injection of small amounts of hot water. After this temperature jump the sample containing the highly polarised molecules is in liquid state at ambient temperature. The resulting signal enhancement compared to a thermally polarised sample which is used in conventional NMR can reach more than 10e4. 

This strategy makes it possible to detect either molecules at very low concentration or acquire their NMR signal in a single excitation even for 13C NMR. The project involves the investigation and improvement of several aspects of the experimental protocol: 

a) Testing novel radicals for their DNP properties. In particular, we are interested to developed strategies to increase the polarisation built-up time so that the overall waiting time for the generation of highly polarised samples can be substantially reduced. 

b) Testing novel ideas to decrease the volume of hot water needed to dissolve the cold sample. In particular, we will investigate the use of infrared lasers and microwaves to assist the melting and dissolution of the sample. 

c) Designing new ideas to mix samples in liquid state rapidly. The motivation is to use highly polarised ligands and monitor binding of these small molecules to larger macromolecules. 

d) Application of the improved strategy to study model ligand- protein systems to measure binding constants, first site of approach etc. 

This project requires an interest in experimental physics and offers training in a very wide range of techniques, including spin dynamics investigations, the testing of novel NMR hardware components and the application of novel NMR strategies to studies of biomolecular model systems. The DNP group in Nottingham currently carries out research in DNP NMR theory and hardwaredevelopment. It has recently received a prestigious Novel Technology Development award by the EPSRC that fund research with the objective to optimise the dissolution DNP NMR strategy. 

References: 

1. Leggett, J et al. Phys. Chem. Chem. Phys. 12(22), 5883-5892, 2010 

2. Ardenkjaer-Larson et al. 2003, Proc. Natl. Acad. Science USA, 100(18) 10158 

For further information contact Walter Köckenberger walter.kockenberger@nottingham.ac.uk or iMR.CDT@warwick.ac.uk. The Centre for Doctoral Training in Integrated Magnetic Resonance is a collaboration between researchers at the Universities of Warwick, St Andrews, Southampton, Aberdeen and Nottingham.

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