Category Archives: NMR

[NMR] NMR facility position available

Dear colleagues:

UC Irvine is looking for a Biomolecular NMR Spectroscopy Manager to oversee the BioMolecular Spectroscopy Facility in the Department of Chemistry. The position is responsible for the technical and administrative needs of the facility. The manager solves structures using NMR analysis, maintains equipment, facilitates billing, collaborates with faculty on applications of NMR in their research, and contributes to faculty research initiatives.

Interested parties should apply at: https://careersucirvine.ttcportals.com/jobs/5388243-assistant-development-engineer. The search has an initial close date of 9/14/20 and may be extended if necessary.

Please feel free to contact me (rwmartin@uci.edu) with questions.

Best,
Rachel

Rachel W. Martin
Professor of Chemistry
and Molecular Biology & Biochemistry
University of California, Irvine
rwmartin@uci.edu
probemonkey.com

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[NMR] Dr. Ieva Goldberga | 10th DNP/NMR Educational Tutorial on July 10

Dear NMR Enthusiast,

The 10th Educational Tutorial will be given by Dr. Ieva Goldberga, a postdoc in Prof. Danielle Laurencin’s lab at University of Montpellier on the topic:

“Relaxation-assisted spectral editing in solid-state NMR spectroscopy of biological materials”.

Abstract:

Relaxation analysis in heterogeneous systems can be complicated due to overlapping resonances. In this tutorial, we will consider the use of the inverse Laplace transform to process biexponential relaxation decays to extract information from complex unresolved spectra. The first part will cover ILT and its use in NMR spectroscopy; the second part will consider this methodology in biological materials: collagen and bone.

Speaker’s biography:

2015: MChem, University of Southampton (Dr. Marina Carravetta) 

2020: PhD Chemistry, University of Cambridge (Prof. Melinda J. Duer) 

2019- present: Postdoc at University of Montpellier (Dr. Danielle Laurencin)

Here are the webinar details:

Time: Friday, July 10, 2020, 08:30 AM California or 5:30 PM Paris or 9:00 PM Delhi

Join Meeting: https://ucsb.zoom.us/j/92480496788

Meeting ID: 924 8049 6788

Best regards,

Global NMR Discussion Meetings

PS. We are glad that you are liking our tutorials. In case you missed it or want to hear it again, here is the link to our previous sessions:

https://www.youtube.com/channel/UCMDyuVI6NMYzR3LByZWP4sg

Please subscribe to our YouTube channel.

[Organizers:

Adrian Draney (Guido Pintacuda Lab, CRMN lyon)

Amrit Venkatesh (Aaron Rossini Lab, Iowa)

Asif Equbal (Songi Han Lab, UCSB)

Blake Wilson (Robert Tycko Lab, NIH)

Michael Hope (Lyndon Emsley Lab, EPFL)

Mona Mohammadi (Alexej Jerschow, NYU)

PinelopiMoutzouri (Lyndon Emsley Lab, EPFL) ]

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[NMR] NMR Instrumentation Facility Manager at Miami University, Ohio

Dear Colleagues,

We have an opening for a NMR Instrumentation Facility Manager at Miami University

best regards,

Gary

Applications are invited for a full-time NMR instrumentation facility manager in the Department of Chemistry and Biochemistry at Miami University, Oxford, OH. Job Description: manage, administer, instruct, train, and maintain an instrumentation facility for NMR researchers. The department has several NMR spectrometers operating up to 850 MHz and several MS instruments. Requirements: Ph.D. in Chemistry or a related field, with expertise in the area of NMR spectroscopy. Experience with MS instrumentation is desired. Preference will be given to applicants with experience managing an instrumentation facility, maintaining a liquid He recovery system, and training students. The applicant will work under the supervision of the chair of the department. Submit letter of interest, curriculum vitae, and provide the names of three references to: http://jobs.miamioh.edu/cw/en-us/job496688. For inquiries about posting, contact Gary Lorigan at gary.lorigan@miamioh.edu. Screening of applications will begin May 15, 2020 and will continue until the position is filled.

Miami University, an Equal Opportunity/Affirmative Action employer, encourages applications from minorities, women, protected veterans and individuals with disabilities. Miami University prohibits harassment, discrimination and retaliation on the basis of age (40 years or older), color, disability, gender identity or expression, genetic information, military status, national origin (ancestry), pregnancy, race, religion, sex/gender, status as a parent or foster parent, sexual orientation, or protected veteran status in its application and admission processes, educational programs and activities, facilities, programs or employment practices. Requests for reasonable accommodations for disabilities related to employment should be directed to ADAFacultyStaff@MiamiOH.edu or 513-529-3560. As part of the University’s commitment to maintaining a healthy and safe living, learning, and working environment, we encourage you to read Miami University’s Annual Security & Fire Safety Report at: http://www.MiamiOH.edu/campus-safety/annual-report/index.html, which contains information about campus safety, crime statistics, and our drug and alcohol abuse and prevention program designed to prevent the unlawful possession, use, and distribution of drugs and alcohol on campus and at university events and activities. This report also contains information on programs and policies designed to prevent and address sexual violence, domestic violence, dating violence, and stalking. Each year, email notification of this website is made to all faculty, staff, and enrolled students. Written notification is also provided to prospective students and employees. Hard copies of the Annual Security & Fire Safety Report may be obtained from the Miami University Police Department at (513) 529-2223. A criminal background check is required. All campuses are smoke- and tobacco-free. 

Gary A. Lorigan

John W. Steube Professor 

Department of Chemistry and Biochemistry

Miami University

651 E. High St.

Oxford, Ohio 45056

Office: 137 Hughes Laboratories

Phone: (513) 529-3338

Fax: (513) 529-5715

e-mail: gary.lorigan@miamioh.edu

web: www.users.muohio.edu/lorigag/index.html

EPR facility: epr.muohio.edu

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TmDOTP: An NMR-based thermometer for magic angle spinning NMR experiments

Knowing the actual sample temperature in a solid-state NMR experiment is crucial in many ways. Many different approaches exist from measuring the chemical shift difference in spectra of ethylene glycol (solution-state NMR spectroscopy) to measuring the peak position in lead nitrate or the T1 relaxation times of KBr (solid-state NMR spectroscopy). All of these methods have their pros and cons. This approach using TmDOTP, having a temperature coefficient of 1ppm/K and being inert to biopolymers is a valuable addition to the ssNMR toolbox.

Zhang, Dongyu, Boris Itin, and Ann E. McDermott. “TmDOTP: An NMR-Based Thermometer for Magic Angle Spinning NMR Experiments.” Journal of Magnetic Resonance 308 (November 1, 2019): 106574.

https://doi.org/10.1016/j.jmr.2019.106574

Solid state NMR is a powerful tool to probe membrane protein structure and dynamics in native lipid membranes. Sample heating during solid state NMR experiments can be caused by magic angle spinning and radio frequency irradiation such heating produces uncertainties in the sample temperature and temperature distribution, which can in turn lead to line broadening and sample deterioration. To measure sample temperatures in real time and to quantify thermal gradients and their dependence on radio frequency irradiation or spinning frequency, we use the chemical shift thermometer TmDOTP, a lanthanide complex. The H6 TmDOTP proton NMR peak has a large chemical shift (−176.3 ppm at 275 K) and it is well resolved from the protein and lipid proton spectrum. Compared to other NMR thermometers (e.g., the proton NMR signal of water), the proton spectrum of TmDOTP, particularly the H6 proton line, exhibits very high thermal sensitivity and resolution. In MAS studies of proteoliposomes we identify two populations of TmDOTP with differing temperatures and dependency on the radio frequency irradiation power. We interpret these populations as arising from the supernatant and the pellet, which is sedimented during sample spinning. In this study, we demonstrate that TmDOTP is an excellent internal standard for monitoring real-time temperatures of biopolymers without changing their properties or obscuring their spectra. Real time temperature calibration is expected to be important for the interpretation of dynamics and other properties of biopolymers.

3D-printed dissolvable inserts for efficient and customizable fabrication of NMR transceiver coils

This article is not directly related to DNP but describes some where nice concepts to make variable pitch NMR coils.

Kelz, Jessica I., John E. Kelly, and Rachel W. Martin. “3D-Printed Dissolvable Inserts for Efficient and Customizable Fabrication of NMR Transceiver Coils.” Journal of Magnetic Resonance 305 (August 2019): 89–92.

https://doi.org/10.1016/j.jmr.2019.06.008.

We describe a simplified method for improving the reproducibility of transceiver coil fabrication for nuclear magnetic resonance (NMR) through single-use templates made from 3D-printed polymer forms. The utility of dissolvable inserts for achieving performance enhanced resonators (DIAPERs) is tested herein by a comparison of RF homogeneity along the rotor axis for variable-pitch solenoids with different inter-turn spacing. Simulated B1 field profiles are compared to experimental homogeneity measurements, demonstrating the potential of this approach for making NMR coils quickly and reproducibly.

[NMR] Solid-State NMR specialist permanent position – EPFL Lausanne, Switzerland #DNPNMR

The NMR platform of the Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland, is looking for a solid-state NMR specialist (permanent position). 

As a member of the NMR service of the EPFL’s chemistry institute, you will be responsible of all the analysis of the researchers willing to characterize their samples by solid-state NMR. You will have all the freedom to propose new methods to our users in a solving problems approach, using mainly two 400 MHz routine spectrometers, but having as well access to machines used by research group (Emsley group) working at 400, 500 and 900 MHz, equipped for LT/DNP-MAS and VF-MAS (111kHz, 0.7mm).

You will be the reference person in charge of the solid state spectrometers of the EPFL NMR platform (5 spectrometers at 400-900 MHz, 2 gyrotrons and 3 LT-MAS cabinets over a total of 22 NMR machines) and, in coordination with our technical specialist, you will be responsible of the maintenance of these machines.

If you are interested, you can find more information here

https://recruiting.epfl.ch/Vacancies/984/Description/3 (francais)

https://recruiting.epfl.ch/Vacancies/984/Description/2 (English)

Do not hesitate to share.

Regards

Aurélien Bornet

Scientific Collaborator

ISIC-NMR Service

Ecole Polytechnique Fédérale de Lausanne

BCH 1538 (Batochime UNIL)

Av. Forel 2

CH-1015 Lausanne

Tel: +41 (0)21 693 71 61

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[NMR] PhD in computational spin dynamics

Peter Hore peter.hore@chem.ox.ac.uk via listes.univ-paris-diderot.fr 

PhD in computational spin dynamics at the Universities of Oxford and Oldenburg

We are seeking a graduate student with experience of, or an interest in, computational NMR or EPR who might be nervous of committing to a PhD in Brexit Britain but who would still welcome a strong connection to a leading UK university.

Based in the Department of Physics at the University of Oldenburg, Germany, the student will be supervised by Peter Hore (Department of Chemistry, University of Oxford). The position is funded by the DFG (https://www.sfb1372.de/) as part of Sonderforschungsbereich 1372: Magnetoreception and navigation in vertebrates: from biophysics to brain and behaviour. Further details can be found at: https://www.sfb1372.de/sig01-2.

For informal enquiries please email peter.hore@chem.ox.ac.uk.

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[NMR] Fwd: Technical/Scientific collaborator position in magnetic resonance at the University of Freiburg, Germany #EPR

De: Stefan Weber <Stefan.Weber@physchem.uni-freiburg.de>

Objet: Technical/Scientific collaborator position in magnetic resonance at the University of Freiburg, Germany

Date: 12 avril 2019 à 21:43:58 UTC+2

Dear colleagues,

Applications are invited for the post of technical/scientific collaborator to be held in the Institute of Physical Chemistry at the University of Freiburg, with effect from 1 July 2019. The appointment is full time and based on an indefinite term contract (salary according to TV-L E13). The successful candidate will be responsible for the technical administration and management of the magnetic resonance laboratories (NMR and EPR). S/he should have earned a university degree and hold a doctorate in either chemistry or physics. An excellent knowledge of magnetic resonance instrumentation for the development of home-built spectrometers and probe heads (in collaboration with the local electronics and mechanics workshops) and the operation and maintenance of the NMR and EPR instruments of the institute (including the lasers used for transient experiments), is required. The candidate is further expected to have vast experience with the measurement, analysis and interpretation of NMR and EPR spectra. Queries about the post and applications (including a letter of motivation, CV, and degree certificates with grades in a single PDF file), stating the job reference number 00000446, should be addressed to Prof. Dr. Stefan Weber, Albertstr. 21, 79104 Freiburg; E-mail: stefan.weber@physchem.uni-freiburg.de.

The closing date for applications is 24 April 2019. For further details, please see: http://www.uni-freiburg.de/verwaltung/stellenboerse/00000446 (only in German)

Kind regards,

Stefan Weber

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Open Position at Bridge12 #DNPNMR

Bridge12 is hiring. We have an open position for a scientist in the area of instrument development for magnetic resonance spectroscopy (EPR, NMR, DNP).

As a scientist at Bridge12, you will work on multidisciplinary projects covering large aspects of magnetic resonance, instrumentation design, development of prototypes and conduct research. The position requires creativity in a wide range of areas of magnetic resonance spectroscopy including NMR and EPR spectroscopy, imaging, and instrument development. We are looking for a highly motivated, highly organized individual who enjoys an innovative, interdisciplinary environment and the challenges that come with manufacturing high-tech, scientific instrumentation. You will work out of the Bridge12 facilities in Framingham, MA with only occasional travel (conferences, tradeshows etc.).

The complete job ad can be found here:

http://www.bridge12.com/scientist-magnetic-resonance-spectroscopy-2/

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