Category Archives: Hyperpolarization

Combustion resistance of the 129Xe hyperpolarized nuclear spin state

Stupic, K.F., et al., Combustion resistance of the 129Xe hyperpolarized nuclear spin state. Phys. Chem. Chem. Phys., 2013. 15(1): p. 94-97.

http://dx.doi.org/10.1039/C2CP43382F

Using a methane-xenon mixture for spin exchange optical pumping, MRI of combustion was enabled. The 129Xe hyperpolarized nuclear spin state was found to sufficiently survive the complete passage through the harsh environment of the reaction zone. A velocity profile (Vz(z)) of a flame was recorded to demonstrate the feasibility of MRI velocimetry of transport processes in combustors.

Combustion resistance of the 129Xe hyperpolarized nuclear spin state

Stupic, K.F., et al., Combustion resistance of the 129Xe hyperpolarized nuclear spin state. Phys. Chem. Chem. Phys., 2013. 15(1): p. 94-97.

http://dx.doi.org/10.1039/C2CP43382F

Using a methane-xenon mixture for spin exchange optical pumping, MRI of combustion was enabled. The 129Xe hyperpolarized nuclear spin state was found to sufficiently survive the complete passage through the harsh environment of the reaction zone. A velocity profile (Vz(z)) of a flame was recorded to demonstrate the feasibility of MRI velocimetry of transport processes in combustors.

HyperSPASM NMR: A new approach to single-shot 2D correlations on DNP-enhanced samples

Donovan, K.J. and L. Frydman, HyperSPASM NMR: A new approach to single-shot 2D correlations on DNP-enhanced samples. J. Magn. Reson., 2012. 225(0): p. 115-119.

http://dx.doi.org/10.1016/j.jmr.2012.10.006

Dissolution DNP experiments are limited to a single or at most a few scans, before the non-Boltzmann magnetization has been consumed. This makes it impractical to record 2D NMR data by conventional, t1-incremented schemes. Here a new approach termed HyperSPASM to establish 2D heteronuclear correlations in a single scan is reported, aimed at dealing with this kind of challenge. The HyperSPASM experiment relies on imposing an amplitude-modulation of the data by a single Δt1 indirect-domain evolution time, and subsequently monitoring the imparted encoding on separate echo and anti-echo pathway signals within a single continuous acquisition. This is implemented via the use of alternating, switching, coherence selection gradients. As a result of these manipulations the phase imparted by a heteronucleus over its indirect domain evolution can be accurately extracted, and 2D data unambiguously reconstructed with a single-shot excitation. The nature of this sequence makes the resulting experiment particularly well suited for collecting indirectly-detected HSQC data on hyperpolarized samples. The potential of the ensuing HyperSPASM method is exemplified with natural-abundance hyperpolarized correlations on model systems.

HyperSPASM NMR: A new approach to single-shot 2D correlations on DNP-enhanced samples

Donovan, K.J. and L. Frydman, HyperSPASM NMR: A new approach to single-shot 2D correlations on DNP-enhanced samples. J. Magn. Reson., 2012. 225(0): p. 115-119.

http://dx.doi.org/10.1016/j.jmr.2012.10.006

Dissolution DNP experiments are limited to a single or at most a few scans, before the non-Boltzmann magnetization has been consumed. This makes it impractical to record 2D NMR data by conventional, t1-incremented schemes. Here a new approach termed HyperSPASM to establish 2D heteronuclear correlations in a single scan is reported, aimed at dealing with this kind of challenge. The HyperSPASM experiment relies on imposing an amplitude-modulation of the data by a single Δt1 indirect-domain evolution time, and subsequently monitoring the imparted encoding on separate echo and anti-echo pathway signals within a single continuous acquisition. This is implemented via the use of alternating, switching, coherence selection gradients. As a result of these manipulations the phase imparted by a heteronucleus over its indirect domain evolution can be accurately extracted, and 2D data unambiguously reconstructed with a single-shot excitation. The nature of this sequence makes the resulting experiment particularly well suited for collecting indirectly-detected HSQC data on hyperpolarized samples. The potential of the ensuing HyperSPASM method is exemplified with natural-abundance hyperpolarized correlations on model systems.

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