Flavell, R.R., et al., Application of Good\’s buffers to pH imaging using hyperpolarized (13)C MRI. Chem Commun (Camb), 2015. 51(74): p. 14119-22.
N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good\’s buffers, was applied to pH imaging using hyperpolarized (13)C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its (13)C chemical shift within the physiologic range.